Ranjan Behera
University of Georgia
7 Papers
173 Citations
Ranjan Behera is an academic researcher from University of Georgia. The author has contributed to research in topics: Trypanosoma brucei & Lapatinib. The author has an hindex of 6, co-authored 7 publications.
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Papers
Kinase Scaffold Repurposing for Neglected Disease Drug Discovery: Discovery of an Efficacious, Lapatanib-Derived Lead Compound for Trypanosomiasis
Gautam Patel,Caitlin E. Karver,Ranjan Behera,Paul J. Guyett,Catherine Sullenberger,Peter M. Edwards,Norma Roncal,Kojo Mensa-Wilmot,Michael P. Pollastri +8 more
TL;DR: This work reports promising activity of analogues of 1, which provided an excellent starting point for optimization of the chemotype, and compound optimization that has led to synthesis of several potent 4-anilinoquinazolines, including NEU617, 23a, a highly potent, orally bioavailable inhibitor of trypanosome replication.
Lapatinib-Binding Protein Kinases in the African Trypanosome: Identification of Cellular Targets for Kinase-Directed Chemical Scaffolds
Samiksha Katiyar,Irina Kufareva,Ranjan Behera,Sarah M. Thomas,Yuko Ogata,Michael P. Pollastri,Ruben Abagyan,Kojo Mensa-Wilmot +7 more
TL;DR: The studies present novel targets of kinase-directed drugs in the trypanosome, and offer the 4-anilinoquinazoline and pyrrolopyrimidines as scaffolds worthy of medicinal chemistry and structural biology campaigns to develop them into anti-trypanosomes drugs.
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Evaluation of aromatic 6-substituted thienopyrimidines as scaffolds against parasites that cause trypanosomiasis, leishmaniasis, and malaria
Jennifer L. Woodring,Gautam Patel,Jessey Erath,Ranjan Behera,Patricia J. Lee,Susan E. Leed,Ana Rodriguez,Richard J. Sciotti,Kojo Mensa-Wilmot,Michael P. Pollastri +9 more
TL;DR: The discovery of two analogs with sub-micromolar potencies for T. cruzi and Plasmodium falciparum were discovered, along with an analog with considerable potency against Leishmania major amastigotes, and the value of concurrent screening of a chemical library against different protozoan parasites is highlighted.
New Chemical Scaffolds for Human African Trypanosomiasis Lead Discovery from a Screen of Tyrosine Kinase Inhibitor Drugs
TL;DR: A focused screen of protein tyrosine kinase inhibitors (PTKIs) targeting against human PTKs could be hits for antitrypanosomal lead discoveries as mentioned in this paper.
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New Chemical Scaffolds for Human African Trypanosomiasis Lead
Ranjan Behera,Sarah M. Thomas,Kojo Mensa-Wilmot +2 more
- 01 Jan 2014
TL;DR: It is proposed that the 4-anilinoquinazoline and pyrrolopyrimidine scaffolds of lapatinib, CI-1033, and AEE788 are worth optimizing against T. brucei in medicinal chemistry campaigns to discover new drugs against HAT.
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