Rangaiah Shashidharamurthy
Philadelphia College of Osteopathic Medicine
43 Papers
121 Citations
Rangaiah Shashidharamurthy is an academic researcher from Philadelphia College of Osteopathic Medicine. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 21, co-authored 43 publications. Previous affiliations of Rangaiah Shashidharamurthy include Vanderbilt University & University of Mysore.
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Papers
Mechanism of Chaperone Function in Small Heat Shock Proteins DISSOCIATION OF THE HSP27 OLIGOMER IS REQUIRED FOR RECOGNITION AND BINDING OF DESTABILIZED T4 LYSOZYME
TL;DR: Correlation of binding isotherms with size exclusion chromatography analysis of the Hsp27 oligomer equilibrium demonstrates that the multimer is the binding-competent state, suggesting a central role for the oligomeric equilibrium in regulating the chaperone activity of sHSP.
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Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom.
TL;DR: Purification and characterization of hyaluronidase from Indian cobra (Naja naja) venom and systematic evaluation of the spreading property of the enzyme are described and corroborate the plausible in vivo degradation of hy aluronan in the extracellular matrix (ECM).
134
Lipocalin 2 Deficiency Dysregulates Iron Homeostasis and Exacerbates Endotoxin-Induced Sepsis
Gayathri Srinivasan,Jesse D. Aitken,Benyue Zhang,Frederic A. Carvalho,Benoit Chassaing,Rangaiah Shashidharamurthy,Niels Borregaard,Dean P. Jones,Andrew T. Gewirtz,Andrew T. Gewirtz,Matam Vijay-Kumar +10 more
TL;DR: Desferroxamine, an iron chelator, significantly protects Lcn2KO mice from LPS-induced toxicity, including mortality, suggesting that Lcn1 may act as an antioxidant in vivo by regulating iron homeostasis, and its small size and simple structure may make LCN2 a deployable treatment for sepsis.
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Variations in biochemical and pharmacological properties of Indian cobra (Naja naja naja) venom due to geographical distribution.
TL;DR: Indian cobra venom obtained from three different geographical regions was studied in terms of electrophoretic pattern, biochemical and pharmacological activities and SDS-PAGE banding pattern revealed significant variation in the protein constituents of the three regional venoms.
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Microbiota-Inducible Innate Immune Siderophore Binding Protein Lipocalin 2 Is Critical for Intestinal Homeostasis
Vishal Singh,Beng San Yeoh,Benoit Chassaing,Benyue Zhang,Piu Saha,Xia Xiao,Deepika Awasthi,Rangaiah Shashidharamurthy,Madhu Dikshit,Andrew T. Gewirtz,Matam Vijay-Kumar +10 more
TL;DR: Lcn2 is a bacterially induced, MyD88-dependent protein that plays an important role in gut homeostasis and a pivotal role on challenge and therapeutic manipulation of Lcn2 levels may provide a strategy to help manage diseases driven by alteration of the gut microbiota.
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