The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression of GPC3 The invention provides novel antibodies that specifically bind to glypican-3 (GPC3) The invention also relates to a fully human chimeric antigen receptor (CAR) wherein the CAR is able to target GPC3

Glypican-3-specific antibody and uses thereof

Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel methods for improving overall reprogramming efficiency with low number of blood progenitor cells.

Generation of induced pluripotent stem cells from small volumes of peripheral blood

According to the present invention, there are provided a method for producing a human T cell, which comprises the steps of inducing an iPS cell from a human T cell, and differentiating the iPS cell into a T cell; a pharmaceutical composition comprising the T cell produced by the method; and a method for cell-based immunotherapy using the method.

Method for reconstructing immune function using pluripotent stem cells

The invention generally regards methods for providing ematopoietic cells and precursors of hematopoietic cells from a variety of cell sources, such as pluripotent stem cells or somatic cells. Also provided are therapeutic compositions including the provided hematopoietic cells and precursors of hematopoietic cells, and methods of using such for the treatment of subjects.

Hematopoietic precursor cell production by programming

The invention provides an automated system for producing induced pluripotent stem cells (iPSCs) from adult somatic cells Further, the system is used for producing differentiated adult cells from stem cells The invention system is useful for isolating somatic cells from tissue samples, producing iPSC lines from adult differentiated cells by reprogramming such cells, identifying the pluripotent reprogrammed adult cells among other cells, and expanding and screening the identified reprogrammed cells

Automated system for producing induced pluripotent stem cells or differentiated cells

Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34 + hematopoietic cells, such as human CD34 + blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.

Reprogramming t cells and hematopoietic cells

Umprogrammierung von T-Zellen und hämatopoetischen Zellen

La presente invention concerne des procedes et des compositions lies a la production de cellules souches pluripotentes induites (cellules iPS). Par exemple, des cellules souches pluripotentes induites peuvent etre creees a partir de cellules hematopoietiques CD34 + , telles que les cellules souches sanguines humaines CD34 + , ou de lymphocytes T. L'invention concerne egalement diverses lignees cellulaires d'iPS. Dans certains modes de realisation, l'invention concerne de nouvelles cellules souches pluripotentes induites ayant un genome comprenant un remaniement genetique des recepteurs de lymphocytes T.

Reprogrammation de lymphocytes t et de cellules hématopoïétiques

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Reprogramming t cells and hematopoietic cells

Umprogrammierung von T-Zellen und hämatopoetischen Zellen

Reprogrammation de lymphocytes t et de cellules hématopoïétiques