Randy L. Jirtle
North Carolina State University
62 Papers
399 Citations
Randy L. Jirtle is an academic researcher from North Carolina State University. The author has contributed to research in topics: Genomic imprinting & Epigenetics. The author has an hindex of 39, co-authored 60 publications. Previous affiliations of Randy L. Jirtle include University of Bedfordshire & Duke University.
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Papers
Environmental epigenomics and disease susceptibility.
TL;DR: An increasing body of evidence from animal studies supports the role of environmental epigenetics in disease susceptibility and recent studies have demonstrated for the first time that heritable environmentally induced epigenetic modifications underlie reversible transgenerational alterations in phenotype.
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Transposable elements: targets for early nutritional effects on epigenetic gene regulation.
TL;DR: The results show that dietary methyl supplementation of a/a dams with extra folic acid, vitamin B12, choline, and betaine alter the phenotype of their Avy/a offspring via increased CpG methylation at the AvY locus and that the epigenetic metastability which confers this lability is due to the Avy transposable element.
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development.
TL;DR: This paper showed that maternal exposure to bisphenol A (BPA), a high-production-volume chemical used in the manufacture of polycarbonate plastic, is associated with higher body weight, increased breast and prostate cancer, and altered reproductive function.
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Maternal Genistein Alters Coat Color and Protects Avy Mouse Offspring from Obesity by Modifying the Fetal Epigenome
TL;DR: It is reported that maternal dietary genistein supplementation of mice during gestation, at levels comparable with humans consuming high-soy diets, shifted the coat color of heterozygous viable yellow agouti (Avy/a) offspring toward pseudoagouti, providing the first evidence that in utero dietarygenistein affects gene expression and alters susceptibility to obesity in adulthood by permanently altering the epigenome.
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The measured electrical properties of normal and malignant human tissues from 50 to 900 MHz
TL;DR: To illustrate a potential use of these data in hyperthermia applications, frequency-selective heating of malignant tissue (modeled as a sphere) surrounded by host normal tissue is calculated from the measured electrical properties for certain tissues.
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