Randy J. Smith
Brookhaven National Laboratory
18 Papers
129 Citations
Randy J. Smith is an academic researcher from Brookhaven National Laboratory. The author has contributed to research in topics: Synchrotron radiation & Microprobe. The author has an hindex of 10, co-authored 18 publications.
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Papers
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease.
TL;DR: A strong spatial correlation has been observed between elevated beta-sheet content in Abeta plaques and accumulated Cu and Zn ions, emphasizing an association of metal ions with amyloid formation in AD.
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FTIR spectroscopic imaging of protein aggregation in living cells
TL;DR: This review focuses on how FTIR spectroscopy and spectroscopic microscopy are being used to evaluate the structural changes in disease-related proteins both in vitro and directly within cells and tissues.
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Synchrotrons versus globars, point-detectors versus focal plane arrays: Selecting the best source and detector for specific infrared microspectroscopy and imaging applications
Lisa M. Miller,Randy J. Smith +1 more
TL;DR: In this article, the differences between conventional globar IR sources and synchrotron light, and between a single-point-detector and focal plane array (FPA) are compared.
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Synchrotron X-ray 2D and 3D elemental imaging of CdSe/ZnS quantum dot nanoparticles in Daphnia magna.
TL;DR: 3D tomography confirmed that the QDs appeared to be confined to the gut area of the organism, and there was no evidence of further assimilation into the organism.
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In vitro efficiency and mechanistic role of indocyanine green as photodynamic therapy agent for human melanoma.
Abdel-Megid Mamoon,Amira M. Gamal–Eldeen,Meghan E. Ruppel,Randy J. Smith,Thomas Tsang,Lisa M. Miller,Lisa M. Miller +6 more
TL;DR: Indocyanine green/PDT can efficiently and rapidly induce apoptosis in human melanoma cells and it can be considered as a new therapeutic approach for topical treatment of melanoma.
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