Randy D. Gascoyne
BC Cancer Agency
603 Papers
4.3K Citations
Randy D. Gascoyne is an academic researcher from BC Cancer Agency. The author has contributed to research in topics: Diffuse large B-cell lymphoma & Lymphoma. The author has an hindex of 120, co-authored 603 publications. Previous affiliations of Randy D. Gascoyne include Queen Mary University of London & Vancouver General Hospital.
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Papers
Clinicopathologic Subtypes of Mantle Cell Lymphoma (MCL) Show Distinct Patterns of Genetic Copy Number Alteration.
Ronald J. deLeeuw,Chad A. Malloff,Lindsey R. Kimm,Joseph M. Connors,Martin J. S. Dyer,Randy D. Gascoyne,Wan L. Lam +6 more
TL;DR: Multiple genomic regions and cancer related genes show a differential pattern of altered copy number distribution between MCL subtypes, and likely contribute to the different clinicopathologic subtypes of MCL cases.
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•Journal Article
Identification of novel regions of genomic copy number alteration in mantle cell lymphoma by array comparative genomic hybridization to a 97,299 element whole genome DNA array
Ronald J. deLeeuw,Jonathan J. Davies,Laura-Jane Henderson,Gwyn Bebb,Randy D. Gascoyne,Douglas E. Horsman,Wan L. Lam +6 more
TL;DR: Malloff et al. as mentioned in this paper used Comparative Genome Hybridization (CGH) to align high resolution genomic profiles from multiple MCL cell lines to reveal minimal regions of alteration important in the pathogenesis of MCL.
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Protein Tyrosine Phosphatase Type-1 (PTPN1) Is Frequently Mutated In Primary Mediastinal B Cell Lymphoma and Hodgkin Lymphoma
Jay Gunawardana,Fong Chun Chan,Adele Telenius,Bruce Woolcock,Robert Kridel,King Tan,Susana Ben Neriah,Raymond S. Lim,Sanja Rogic,Merrill Boyle,Chrystelle Guiter,Karen Leroy,Corinne Haioun,Lisa M. Rimsza,Philippe Gaulard,Kerry J. Savage,Joseph M. Connors,Marco A. Marra,Sohrab P. Shah,Randy D. Gascoyne,Christian Steidl +20 more
TL;DR: It is hypothesized that constitutively active Janus kinase-Signal transducer and activation of transcription (JAK-STAT) observed in HL and PMBCL are in part due to a mutated PTPN1 gene with an impaired functional ability to dephosphorylate this constitutive signaling pathway.
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A Comparison of Gene Expression Pattern in Major Histocompatibility Class II-Low Diffuse Large B-Cell Lymphoma with Plasmablastic Lymphoma.
Sarah T. Wilkinson,Roshanak Bob,Harald Stein,Mark Schwartz,Rita M. Braziel,Randy D. Gascoyne,Lisa M. Rimsza +6 more
TL;DR: This study questioned whether DLBCL cases that have low MHCII expression have a similar gene expression pattern to PBL, and confirmed the hypothesis that M HCII(-)DLBCL have a more plasma cell-like expression pattern than MHC II(+) DLBCl.
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Frequent Genetic Alterations of PI3K-AKT Pathway and Their Clinical Significance in Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma
Daisuke Ennishi,Ali Bashashati,Saeed Saberi,Anja Mottok,Barbara Meissner,Merrill Boyle,Susana Ben-Neriah,Robert Kridel,David Dominguez-Sola,Kerry J. Savage,Laurie H. Sehn,Joseph M. Connors,Ryan D. Morin,Ryan D. Morin,Marco A. Marra,Sohrab P. Shah,Christian Steidl,David W. Scott,Randy D. Gascoyne +18 more
TL;DR: Genetic alterations involved in the PI3K-AKT pathway were frequently observed in GCB-DLBCL and were associated with activation of the pathway and inferior outcomes, which has hampered the development of targeted therapies with specific efficacy in this subtype.
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