Randy D. Gascoyne
BC Cancer Agency
603 Papers
4.3K Citations
Randy D. Gascoyne is an academic researcher from BC Cancer Agency. The author has contributed to research in topics: Diffuse large B-cell lymphoma & Lymphoma. The author has an hindex of 120, co-authored 603 publications. Previous affiliations of Randy D. Gascoyne include Queen Mary University of London & Vancouver General Hospital.
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Papers
Genetic Alterations Detected by High-Resolution Array Comparative Genomic Hybridization in Microdissected HRS Cells Correlate with Treatment Outcome in Classical Hodgkin Lymphoma
Christian Steidl,Adele Telenius,Sohrab P. Shah,K-John Cheung,Lorena Barclay,Joseph M. Connors,Douglas E. Horsman,Randy D. Gascoyne +7 more
TL;DR: The combination of laser microdissection with subsequent WGA and high resolution array CGH provides a robust and sensitive platform for detecting chromosomal imbalances in microdissected HRS cells and found copy number alterations that are significantly associated with disease progression which, therefore, could serve as predictive factors for treatment outcome.
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Long-term follow up of limited stage primary testicular lymphoma: Outcome and patterns of relapse after combined-modality treatment
Abdulwahab J. Al-Tourah,Jean M. Connors,Randy D. Gascoyne,Paul Hoskins,Susan E. O'Reilly,Tamara Shenkier,Nick Voss,Richard Klasa +7 more
TL;DR: Patients with limited stage primary testicular lymphoma who undergo combined-modality treatment are at risk for late relapses at extranodal sites, with particular predilection for skin and brain parenchyma but not leptomeninges.
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BCL11AXL Protein: Its Distribution in Normal and Malignant Tissues and Use as a Marker for Plasmacytoid Dendritic Cells.
Karen Pulford,Alison H. Banham,Linden Lyne,Margaret Jones,Greg Ippolito,Hiu Liu,Phil W. Tucker,Giovanna Roncador,Elena Lucas,Sally Ashe,Elizabeth Stockwin,Renata Walewska,Elisabeth L. Karran,Randy D. Gascoyne,David Y. Mason,Martin J. S. Dyer +15 more
TL;DR: Publicly available microarray expression data are consistent with these findings, showing BCL11A transcripts to be present at high levels in peripheral blood B cells, in tonsil, lymph node and fetal brain with the highest expression in pDCs, and high level expression in CD74+CD68+CD123+ plasmacytoid dendritic cells (pDCs).
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Single Cell Mass Cytometry for Phenotypic Analysis of Diffuse Large B-Cell Lymphoma
Manabu Kusakabe,Guillermo Simkin,Justin Meskas,Chaoran Zhang,Daisuke Ennishi,Merrill Boyle,David Scott,Christian Steidl,Randy D. Gascoyne,Ryan R. Brinkman,Andrew P. Weng +10 more
TL;DR: Findings suggest intratumoral heterogeneity can be resolved by high dimensional CyTOF analysis and ongoing efforts will focus on determining if phenotypically defined subsets show enrichment for subclonal mutations.
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