Randall Logan
University of Kansas
8 Papers
46 Citations
Randall Logan is an academic researcher from University of Kansas. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 4, co-authored 4 publications.
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Papers
Amine-Containing Molecules and the Induction of an Expanded Lysosomal Volume Phenotype: A Structure–Activity Relationship Study
TL;DR: The present results suggest that a molecule's potency in eliciting an ELVP is influenced by lysosomotropism, amphiphilicity, and its ability to intercalate into biological membranes.
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Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications
TL;DR: It is proposed that drug-drug interactions involving lysosomes represent an important potential source of variability in drug activity and pharmacokinetics and is needed to fully explore the impact of this drug- drug interaction pathway on therapeutic outcomes.
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Time‐Dependent Effects of Hydrophobic Amine‐Containing Drugs on Lysosome Structure and Biogenesis in Cultured Human Fibroblasts
TL;DR: Results show that hydrophobic lysosomotropic drugs can induce their own cellular accumulation in a time-dependent fashion and that this is associated with an expanded lysOSomal volume.
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Evaluating the Roles of Autophagy and Lysosomal Trafficking Defects in Intracellular Distribution-Based Drug-Drug Interactions Involving Lysosomes
TL;DR: It is shown that eight hydrophobic amines, previously characterized as perpetrators in this type of drug-drug interaction, cause a significant expansion in lysosomal volume that was correlated with both the induction of autophagy and with decreases in the efficiency of lysOSomal egress.
22
Analysis of the Anticancer Potential of Green Tea’s EGCG Component to Inhibit Immortal Cells
TL;DR: Results indicated that green tea extract imposed a cytotoxic effect selective to cancer cells while avoiding cytotoxicity to a primary cell model, and showed the potential for green tea extracts containing EGCG to be potential components in cancer therapeutics and/or preventatives.