Randa Abdel Malik
Goethe University Frankfurt
6 Papers
Randa Abdel Malik is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Vascular endothelial growth factor A & Myeloid. The author has an hindex of 6, co-authored 6 publications.
Chat about Author
Papers
Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis
Sofia Iris Bibli,Jiong Hu,Fragiska Sigala,Ilka Wittig,Juliana Heidler,Sven Zukunft,Diamantis I. Tsilimigras,Voahanginirina Randriamboavonjy,Janina Wittig,Baktybek Kojonazarov,Christoph Schürmann,Mauro Siragusa,Daniel Siuda,Bert Luck,Randa Abdel Malik,Konstantinos Filis,George C. Zografos,Chen Chen,Dao Wen Wang,Josef Pfeilschifter,Ralf P. Brandes,Csaba Szabó,Andreas Papapetropoulos,Andreas Papapetropoulos,Ingrid Fleming +24 more
TL;DR: The deletion of CSE from endothelial cells was associated with the accelerated development of endothelial dysfunction and atherosclerosis, effects that were reversed on treatment with a polysulfide donor.
121
AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis
Randa Abdel Malik,Nina Zippel,Timo Frömel,Juliana Heidler,Sven Zukunft,Barbara Walzog,Nariman Ansari,Francesco Pampaloni,Susanne Wingert,Michael A. Rieger,Ilka Wittig,Beate Fisslthaler,Ingrid Fleming +12 more
TL;DR: In this article, the role of AMPα2 subunit in vascular repair after femoral artery ligation was investigated in mice lacking AMPKα2 in myeloid cells (AMPKα2ΔMC).
49
The Histone Demethylase PHF8 Is Essential for Endothelial Cell Migration
Lunda Gu,Juliane Hitzel,Franziska Moll,Christoph Kruse,Randa Abdel Malik,Jens Preussner,Mario Looso,Matthias S. Leisegang,Dieter Steinhilber,Ralf P. Brandes,Christian Fork +10 more
TL;DR: PHF8 by controlling E2F4 expression maintains endothelial function, and chromatin immunoprecipitation revealed that PHF8 reduces the H3K9me2 level at the E2f4 transcriptional start site, demonstrating a direct function of PHf8 in endothelial E 2F4 gene regulation.
Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis
Beate Fisslthaler,Nina Zippel,Randa Abdel Malik,Fredy Delgado Lagos,Sven Zukunft,Janina Thoele,Daniel Siuda,Oliver Soehnlein,Oliver Soehnlein,Ilka Wittig,Juliana Heidler,Andreas Weigert,Ingrid Fleming +12 more
TL;DR: Results indicate that the AMPKα2 subunit in myeloid cells influences DNA methylation and thus protein expression and contributes to the development of atherosclerotic plaques.
Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis
Khader Awwad,Jiong Hu,Lei Shi,Nicole Mangels,Randa Abdel Malik,Nina Zippel,Beate Fisslthaler,Johannes A. Eble,Josef Pfeilschifter,Rüdiger Popp,Ingrid Fleming +10 more
TL;DR: Results indicate that SMOC1 is an ALK5 antagonist produced by endothelial cells that tips TGF-β signalling towards ALK1 activation, thus promoting endothelial cell proliferation and angiogenesis.