Ran Xu
7 Papers
1 Citations
Ran Xu is an academic researcher. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis
Yi Yang,Yifu Zhu,Shuai Zhou,Peipei Tang,Ran Xu,Yuwei Zhang,Dongping Wei,Jian Wen,Rick F. Thorne,X. D. Zhang,Jun-Lin Guan,Lianxin Liu,Min Wu,Song Chen +13 more
TL;DR: This study identifies a key role of STK38L‐TRIM27‐ULK1 signaling axis in negatively controlling autophagy with relevance established in human breast cancer.
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Stub1 maintains proteostasis of master transcription factors in embryonic stem cells.
Mahfuz-Al-Mamun Mamun,Muhammad Riaz Khan,Yifu Zhu,Yuwei Zhang,Shuai Zhou,Ran Xu,Ihtisham Bukhari,Rick F. Thorne,Jinming Li,X. D. Zhang,Guang Zhi Liu,Song Chen,Min Wu,Xiaoyuan Song +13 more
TL;DR: In this article , the E3 ubiquitin ligase Stub1 was identified as a negative regulator of pluripotency and differentiation states of embryonic stem cells (ESCs) using a CRISPR-Cas9 knockout library screen in murine ESCs.
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Lack of transcriptional coordination between mitochondrial and nuclear oxidative phosphorylation genes in the presence of two divergent mitochondrial genomes
TL;DR: Compared transcription, polymorphism, and synonymous codon usage in the mitochondrial and nuclear OXPHOS genes of the DUI species Ruditapes philippinarum using sex- and tissue-specific transcriptomes revealed that mutation bias and translational selection were the major factors affecting thecodon usage bias in different OX PHOS genes.
6
KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.
Chengwan Zhang,Li Shen,Yifu Zhu,Ran Xu,Zhi-Kui Deng,Xiaoning Liu,Yi-Han Ding,Chunling Wang,Yuye Shi,Liye Bei,Dongping Wei,Rick F. Thorne,Xudong Zhang,Xudong Zhang,Liang Yu,Song Chen +15 more
TL;DR: In this article, the authors identify histone lysine demethylases (KDMs) with altered expression in CML and define their contribution to imatinib resistance.
1
Abstract 3687: Disruption of nucleotide homeostasis confers cancer cell susceptibility to oxidative phosphorylation inhibition independently of energy depletion
Yuan Yuan Zhang,Liang Xu,Ting La,Yu Chen Feng,Hai Jie Tang,Ran Xu,Vinod K. Narayana,David P De Souza,Lake-Ee Quek,Jeff Holst,Rick F. Thorne,Mark Baker,Tao Liu,Lei Jin,X. D. Zhang +14 more
TL;DR: Zhao et al. as discussed by the authors showed that disruption of nucleotide homeostasis is a major determinant of cancer cell susceptibility to OXPHOS inhibition, which is a promising avenue for the treatment of cancers that are metabolic flexible and glycolysis competent.