Osteoporosis (OP) is a common metabolic bone disease characterized by loss of bone mass. IL-10 is considered to be a powerful immune and inflammatory suppressor. This study aimed to assess association between genetic loci in IL-10 and susceptibility to OP.Association analysis between IL-10 genetic loci and OP risk through SNPStats online software. FPRP analysis (false-positive report probability) verified whether the positive results were noteworthy findings. Linkage disequilibrium (LD) and haplotype analysis were completed by Haploview 4.2 and SNPStats. Multi-factor dimensionality reduction (MDR) was used to assess interaction of SNP-SNP in susceptibility to OP.Allele "G" of IL-10-rs1554286 (OR = 1.21, p = 0.013), allele "C" of IL-10-rs1518111 (OR = 1.22, p = 0.011), allele "C" of IL-10-rs3024490 (OR = 1.20, p = 0.018), and allele "G" of IL-10-rs1800871 (OR = 1.21, p = 0.015) were risk factors for OP. In females, smoking, drinking, or aging ≤60 years old participants, the above genetic loci are also significantly associated with the increased risk of OP. FPRP analysis showed that all positive results are noteworthy findings. There are significant differences in serum levels of uric acid, mean hemoglobin concentration, or mean hemoglobin among different genotypes of IL-10 gene loci. MDR showed that four loci model composed rs1554286, rs1518111, rs3021094, and rs1800871 is the best model for predicting OP risk.IL-10-rs1554286, -rs1518111, -rs3021094, and -rs1800871 are risk factors for susceptibility to OP. 

Risk Genetic Variants (IL-10) for Osteoporosis in Han Population from Northwest China

Abstract The overall objective of this study was to determine the association between hemoglobin (HGB) and bone mineral density (BMD) in the lumbar and thoracic spine of adults aged ≥ 18 years. This cross-sectional study utilized the non-institutionalized US population from the National Health and Nutrition Survey (NHANES) as the sample source. A multiple linear regression model was used to assess the relationship between HGB and BMD in the lumbar and thoracic spine, with analysis of subgroups conducted according to sex and race. Smooth curve fitting was performed to explore the potential nonlinear relationship. When nonlinearity was found, we further constructed a weighted two-piecewise linear regression model and used a recursive algorithm to calculate the inflection point. After accounting for relevant confounding variables, HGB was found to be negatively associated with lumbar spine BMD in multiple regression models. However, in the subgroup analyses stratified by sex and race, the relationship between HGB and thoracic spine BMD and lumbar spine BMD was only found in women and other races and races that were not recorded. In Non-Hispanic Asian subjects, the relationship between HGB and BMD in the lumbar spine and thoracic spine showed a U-shaped curve. In addition, the relationship between HGB and BMD in the lumbar spine formed an inverted U-shaped curve among participants in other races and those whose race was not reported. Our study shows that HGB has a non-linear relationship with lumbar and thoracic BMD. Further studies are required to elucidate the mechanisms underlying this association. 

/pdf/association-of-hemoglobin-levels-with-bone-mineral-density-217z1ohg.pdf

Association of hemoglobin levels with bone mineral density for adults over 18 years of age: a cross-sectional study

Abstract Aim:The overall object of this study is to find out the association between hemoglobin (HGB) and bone mineral density (BMD) in the lumbar and thoracic spine among adults over the age of 18.Methods:The current cross-sectional study used the non-institutionalised US population from the National Health and Nutrition Survey (NHANES) as the sample source. A multiple linear regression model and smoothed curve fitting were used to show the assessment of the relationship between hemoglobin and bone mineral density in the lumbar and thoracic spine, with analysis of subgroups according to gender and race.Results:After accounting for relevant confounders, HGB was negatively associated with bone mineral density in multiple regression models. In subgroup analyses stratified by sex or race, however, the relationship between HGB and thoracic spine BMD was only found in women and Mexican-Americans, and the association with lumbar spine BMD was present in males and females, Mexican-American and Non-Hispanic White. Among participants in other races and those whose race was not reported, the relationship between HGB with BMD in the lumbar spine and the thoracic spine showed an inverted U-shaped curve (turning point: HGB 11.9 g/dL).Conclusion: HGB was negatively associated with BMD in the lumbar spine and BMD in the thoracic spine. However, this significant correlation varies by gender and race. 

Association of hemoglobin levels with bone mineral density in the thoracic and lumbar spine for adults over 18 years of age: a cross-sectional study

HemoglobinA1c is a Risk Factor for Changes of Heel Bone Mineral Density: A Mendelian Randomization Study

Both anemia and osteoporosis are common in type 2 diabetes mellitus (T2DM). However, the relationship between them remains to be determined. This study showed that anemia was related to osteoporosis in male and female T2DM patients. Diabetes patients with anemia should also be wary of osteoporosis. INTRODUCTION Anemia and osteoporosis are considered complications of type 2 diabetes mellitus (T2DM). However, the relationship between anemia and osteoporosis in the T2DM population remains to be determined. Thus, we planned the present study to verify their relationship. METHODS A retrospective cross-sectional study was performed. The patients were divided into groups according to sex and hemoglobin levels (Q1: ≤ 120, Q2: 120 to ≤ 140, Q3: > 140 in men; Q1: ≤ 110, Q2: 110 to ≤ 130, Q3: > 130 in women). Clinical characteristics and bone mineral density (BMD) were compared. The relationship between anemia and osteoporosis was determined after adjusting for age, diabetic duration, body mass index, alanine aminotransferase, creatinine, HbA1c, and fasting C-peptide. Statistical analysis was performed using SPSS 26.0. RESULTS This study included 2336 patients (1150 men and 1186 postmenopausal women). The percentage of osteoporosis differed by hemoglobin status in both men (Q1: 20.2%, Q2: 15.5%, Q3: 12.4%, P = 0.031) and women (Q1: 51.4%, Q2: 38.0%, Q3: 34.5%, P < 0.001). Q1, with the lowest hemoglobin level, has higher percentage of osteoporosis in men (20.2%) and in women (51.4%). Hip BMD (men: r = 0.168, P < 0.001, women: r = 0.126, P < 0.001) and femur neck BMD (men: r = 0.150, P < 0.001, women: r = 0.134, P < 0.001) were correlated with hemoglobin levels in both sexes. The odds of osteoporosis increased 1.4-fold in men and 2.0-fold in women in the Q1 groups compared with Q3 groups. CONCLUSION Anemia was related to osteoporosis in T2DM patients regardless of sex. Diabetic patients with anemia (men with hemoglobin below 120 g/L and women with hemoglobin below 110 g/L) should also be wary of osteoporosis.

https://link.springer.com/content/pdf/10.1007/s11657-021-01030-4.pdf

Anemia is related to osteoporosis in Chinese type 2 diabetic patients.

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Ran Cui

Author Tools

Chat about Author

Papers

Anemia is related to osteoporosis in Chinese type 2 diabetic patients.