14 Papers
9 Citations
Ran Chen is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Biology & Replication protein A. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Ran Chen include Roy J. and Lucille A. Carver College of Medicine & University of Iowa.
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Papers
Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair.
Ran Chen,Marc S. Wold +1 more
TL;DR: Dynamic DNA binding allows RPA to prevent error‐prone repair of double‐stranded breaks and promote error‐free repair, and suggest a new paradigm where RPA acts as a first responder at sites with ssDNA, thereby actively coordinating DNA repair and DNA synthesis.
Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth.
Yuan Pan,Min Xiong,Min Xiong,Ran Chen,Yu Ma,Courtney Corman,Meron Maricos,Urs Kindler,Marcus Semtner,Yi-Hsien Chen,Sonika Dahiya,David H. Gutmann +11 more
TL;DR: It is shown that the inability of athymic mice to support o-GSC engraftment results from impaired microglia/macrophage function, including reduced expression of Ccr2 and Ccl5, both of which are required for o- GSC Engraftment and Nf1 optic glioma growth.
KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production.
TL;DR: It is demonstrated that f-BRAF expression creates a supportive tumor microenvironment through NFκB-mediated Ccl2 production and microglia recruitment and in vivo, as tumor do not form in Ccr2-deficient mice following f- BRAF-expressing NSC injection.
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Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
Ran Chen,Theresa Okeyo-Owuor,Riddhi M Patel,Emily B. Casey,Andrew Cluster,Wei Yang,Jeffrey A. Magee +6 more
TL;DR: In this paper, the myeloid tumor suppressor KMT2C deletions convey a selective advantage to hematopoietic stem cells (HSCs) after chemotherapy treatment that may precipitate t-MDS/t-AML.
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Single-Molecule Analysis of Replication Protein A-DNA Interactions.
TL;DR: This chapter describes how to express, purify, and label RPA, and how to carry out single-molecule experiments examining RPA-DNA interactions using total internal reflection fluorescence microscopy (TIRFM).
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