Ran Afik
Weizmann Institute of Science
16 Papers
43 Citations
Ran Afik is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 6, co-authored 16 publications.
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Papers
Tumor macrophages are pivotal constructors of tumor collagenous matrix.
Ran Afik,Ehud Zigmond,Milena Vugman,Mordehay Klepfish,Elee Shimshoni,Metsada Pasmanik-Chor,Anjana Shenoy,Elad Bassat,Zamir Halpern,Tamar Geiger,Irit Sagi,Chen Varol +11 more
TL;DR: Tumor-associated macrophages are pivotal constructors of the tumoral ECM structure and molecular composition and orchestrate the buildup of the tumorigenic collagenous ECM niche.
CTLs respond with activation and granule secretion when serving as targets for T-cell recognition.
Oren Milstein,David Hagin,Assaf Lask,Shlomit Reich-Zeliger,Elias Shezen,Eran Ophir,Yaki Eidelstein,Ran Afik,Yaron E. Antebi,Michael L. Dustin,Yair Reisner +10 more
TL;DR: It is demonstrated that CTLs actively respond to recognition by polarizing their cytotoxic granules to the contact area, releasing their lethal cargo, and vigorously proliferating, and these data suggest a novel mechanism in which the entire cascade generally triggered by TCR engagement is "hijacked" in C TLs serving as targets for T cell recognition without TCR ligation.
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Distinct extracellular–matrix remodeling events precede symptoms of inflammation
Elee Shimshoni,Idan Adir,Ran Afik,Inna Solomonov,Anjana Shenoy,Miri Adler,Luca Puricelli,Fabio Sabino,Simonas Savickas,Odelia Mouhadeb,Nathan Gluck,Sigal Fishman,Lael Werner,Tomer-Meir Salame,Dror S. Shouval,Chen Varol,Ulrich auf dem Keller,Alessandro Podestà,Tamar Geiger,Paolo Milani,Uri Alon,Irit Sagi +21 more
TL;DR: This study unexpectedly revealed that even prior to the first clinical symptoms, the colon displays its own unique extracellular-matrix signature and found specific markers of clinical potential, which were also validated in human subjects.
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Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo-induced central memory CD8 T cells.
TL;DR: In conclusion, anti-third-party Tcms, which home to recipient LNs and effectively delete antidonor T cells, could provide an effective and novel tool for overcoming rejection of BM allografts.
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Patent
Anti third party central memory t cells, methods of producing same and use of same in transplantation and disease treatment
Yair Reisner,Yaki Eidelstein,Eran Ophir,Assaf Lask,Ran Afik,Noga Or-Geva,Esther Bachar-Lustig +6 more
- 06 Sep 2012
TL;DR: In this paper, a method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed.
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