BACKGROUND: Vitiligo is an acquired pigmentary cutaneous disease, characterised by the progressive loss of melanocytes, resulting in hypopigmented skin areas which progressively become amelanotic Classically, vitiligo treatments are unsatisfactory and challenging Despite the continuous introduction of new therapies, phototherapy is still the mainstay for vitiligo repigmentationAIM: The aim of this multicenter observational retrospective study was to evaluate the efficacy and safety of the nb - UVB micro - phototherapy (BIOSKIN EVOLUTIONÂ®), used alone or in associations with an oral Janus kinase inhibitor (Tofacitinib citrate), in the treatment of stable or active forms of localised vitiligoMATERIAL AND METHODS: Fifty eight patients had been treated with n-UVB micro-photootherapy (Group A); 9 patients had been treated with phototherapy plus Tofacitinb citrate (Group B)RESULTS: Among Group A, 42 patients (72%) obtained a re-pigmentation rate higher than 75%, with a medium value of 77% 11 patients (19%) achieved a marked improvement of the clinical findings with a repigmentation rate between 50-75%; 4 patients (8%) showed a moderate response with a lesional repigmentation of 25-50% Only one patient (1%) had a poor response to the phototherapeutic treatmentCONCLUSION: Nb - UVB micro-focused phototherapy is one of the most effective therapeutic options for vitiligo treatment The association of micro-focused phototherapy to Tofacitinib citrate seems to provide better clinical results in term of repigmentation rate

/pdf/micro-focused-phototherapy-associated-to-janus-kinase-1arjm45ftr.pdf

Micro - Focused Phototherapy Associated To Janus Kinase Inhibitor: A Promising Valid Therapeutic Option for Patients with Localized Vitiligo.

AIM: A multi - centre two years the long prospective open clinical study was conducted in five countries located in four different continents from May 2015 to evaluate the clinical safety and efficacy of Automatic Biofibre hair implant in male and female androgenetic alopecia. BiofibreÂ®is a CE/TGA certified medical grade polyamide fibre suitable for implantation.MATERIAL AND METHODS: A total of 213 patients were enrolled in the study. Patients were assessed pre -operatively by Hamilton scale grading and the percentage of scalp covered by hair. All the patients underwent Biofibre hair implantation by a standardised surgical technique followed by adequate post-operative care. Efficacy of the implant was evaluated by surgeons and patients bimonthly for the first year and trimonthly during the second year. Any adverse effects were recorded during these visits.RESULTS: At the completion of the study period, a total of 194 patients concluded the trial and the results were statistically evaluated. Both Hamilton scale grading and covered area percent improved at the end of the study, and subjective and objective evaluations revealed satisfactory results. Side effects were reported in only 18 cases (9.27%) which were easily controlled by either topical or systemic treatment in 8 to 10 days.CONCLUSION: Overall a successful result was noticed in 97.94% of patients with great psychological satisfaction.

/pdf/automatic-artificial-hair-implant-safety-and-efficacy-in-2vgdgdllxj.pdf

Automatic Artificial Hair Implant: Safety and Efficacy in Androgenetic Alopecia. A Prospective Study with a Highly Biocompatible Fiber.

Androgenetic alopecia (AGA) is the most common cause of hair loss in men and women Artificial hair implantation is considered an alternative treatment when the donor area is depleted or unsuitable

Artificial hair implantation for hair restoration.

Background: The problem of alopecia affects both sexes at all ages with sometimes significant psychological sequelae. Along with androgenetic alopecia, there are forms of alopecia of various origin as traumatic, surgical, pharmacological and others. In 1993 the first biocompatible fibers (Biofibre®) were developed in Italy by Medicap

Automatic biofiber hair implantan innovative hair restoration technique for the improvement of quality life

Androgenic alopecia affects men and women today, where many factors can be the unknown cause of it. It is essential to find a good, effective, and inexpensive treatment for it, as it is a prevalent dermatological condition. Many drugs like minoxidil (MXD) and finasteride (FNS) are commercially used for its treatment but we are still lacking in terms of a complete cure for alopecia. In this study, we came up with different treatment options for alopecia and assessed their advantages and disadvantages. Not only is the treatment part is essential, but the mode of drug delivery is equally important when it comes to hair and its growth for the maximum output. The following discussion considers the idea of nanoparticles (NPs) loaded with drugs and biomaterials used for the treatment of alopecia.

/pdf/biomaterials-for-treatment-of-baldness-rjtcus0z.pdf

Biomaterials for Treatment of Baldness

Body image refers to how we feel about our bodies. It does not refer to what we actually look like, but rather to our perceptions, opinions and ways of thinking about our appearance. How we feel about our appearance is part of our body image and self-image. The hair is a significant part of this image. The problem of alopecia affects both sexes and all ages with significant sequelae. Along with androgenetic alopecia, there are forms of alopecia of various origins: traumatic, surgical, pharmacological and others. Polyamide artificial hair implant (Biofibre®) is one of the current techniques used to treat this problem.

Biofibre hair implant impact on the quality of life.

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Biofibre hair implant impact on the quality of life.