Ramesh Kumar
Agency for Science, Technology and Research
13 Papers
13 Citations
Ramesh Kumar is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: SUMO protein & Ubiquitin. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of Ramesh Kumar include National University of Singapore & Leiden University Medical Center.
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Papers
The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.
Ramesh Kumar,Ramesh Kumar,Román González-Prieto,Zhenyu Xiao,Matty Verlaan-de Vries,Alfred C.O. Vertegaal +5 more
TL;DR: A method for selective enrichment of ubiquitin substrates for E3 ligases from complex cellular proteomes is described and the SUMO conjugation machinery as direct RNF4 substrates are identified.
p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication.
Constance Qiao Xin Yeo,Irina Alexander,Zhaoru Lin,Shuhui Lim,Obed Akwasi Aning,Ramesh Kumar,Kanda Sangthongpitag,Vishal Pendharkar,Vincent H.B. Ho,Chit Fang Cheok +9 more
TL;DR: It is proposed that p53 acts to prevent DNA topological stress originating from transcription during the S phase and, therefore, promotes normal replication fork progression, and Pharmacologic inhibition of transcription attenuates DNA damage and decreases Topo-II-DNA complexes, restoring cell viability in p53-deficient cells.
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RIF1: a novel regulatory factor for DNA replication and DNA damage response signaling.
Ramesh Kumar,Chit Fang Cheok +1 more
TL;DR: Rif1 role in the maintenance of genomic integrity has been expanded to include the regulation of chromatin structure, replication timing and intra-S phase checkpoint and a summary of these important findings highlighting the various aspects of Rif1 functions is presented.
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RNF4—A Paradigm for SUMOylation-Mediated Ubiquitination
Ramesh Kumar,Kanaga Sabapathy +1 more
TL;DR: How RNF4, which is at the heart of both SUMOylation and ubiquitination, modulates cellular signaling and promotes protein degradation is focused on, and the potential of therapeutically targeting R NF4 to improve cancer treatment is explored.
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Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability.
Ramesh Kumar,Chit Fang Cheok +1 more
TL;DR: It is proposed that unresolved RIF1 protein at sites of DNA damage in PIAS4-depleted cells largely accumulates in S phase, and subsequently leads to DNA double strand breaks, which promotes genomic stability by regulating the timely removal of Rif1 from sites ofDNA damage.