Ramachandran S. Vasan
Boston University
1256 Papers
4.3K Citations
Ramachandran S. Vasan is an academic researcher from Boston University. The author has contributed to research in topics: Framingham Heart Study & Medicine. The author has an hindex of 172, co-authored 1100 publications. Previous affiliations of Ramachandran S. Vasan include University Health Network & Swinburne University of Technology.
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Papers
Pathogenesis of Elevated Peripheral Pulse Pressure: Some Reflections and Thinking Forward
TL;DR: The aorta is no longer regarded as just a passive conduit that transports blood to the vital organs, Rather, it is a complex organ that remodels in dynamic fashion in response to biomechanical stresses that accumulate over the life course.
Prioritizing causal disease genes using unbiased genomic features
Rahul C. Deo,Gabriel Musso,Gabriel Musso,Murat Tasan,Murat Tasan,Paul Ling-Fung Tang,Annie Poon,Christiana Yuan,Janine F. Felix,Ramachandran S. Vasan,Rameen Beroukhim,Rameen Beroukhim,Teresa De Marco,Pui-Yan Kwok,Calum A. MacRae,Frederick P. Roth +15 more
TL;DR: A machine learning approach, Objective Prioritization for Enhanced Novelty (OPEN), is developed, which quantitatively prioritizes gene-disease associations based on a diverse group of genomic features and stands to assist interpretation of large-scale genetic studies without compromising their fundamentally unbiased nature.
Metabolic Cost of Exercise Initiation in Patients With Heart Failure With Preserved Ejection Fraction vs Community-Dwelling Adults.
Ravi V. Shah,Mark W. Schoenike,Miguel Ángel Armengol de la Hoz,Miguel Ángel Armengol de la Hoz,Miguel Ángel Armengol de la Hoz,Thomas F Cunningham,Jasmine B Blodgett,Melissa Tanguay,John A. Sbarbaro,Matthew Nayor,Jennifer N. Rouvina,Alyssa Kowal,Nicholas E. Houstis,Aaron L. Baggish,Jennifer E. Ho,C. Corey Hardin,Rajeev Malhotra,Martin G. Larson,Ramachandran S. Vasan,Gregory D. Lewis +19 more
TL;DR: In this article, the authors defined and quantified the metabolic cost of initiating exercise in individuals with and without heart failure with preserved ejection fraction (HFpEF) and its functional consequences.
Association of Changes in Cardiovascular Health Metrics and Risk of Subsequent Cardiovascular Disease and Mortality.
Bamba Gaye,Bamba Gaye,Gabriel S. Tajeu,Ramachandran S. Vasan,Camille Lassale,Norrina B. Allen,Archana Singh-Manoux,Xavier Jouven,Xavier Jouven +8 more
TL;DR: Improvement in CVH or stable ideal CVH, compared with those with poor CVH over time, is associated with a lower risk of incident cardiovascular disease and all‐cause mortality.
Circulating testosterone and SHBG concentrations are heritable in women: the Framingham Heart Study.
Andrea D. Coviello,Wei V. Zhuang,Kathryn L. Lunetta,Shalender Bhasin,Jagadish Ulloor,Anqi Zhang,David Karasik,Douglas P. Kiel,Ramachandran S. Vasan,Joanne M. Murabito +9 more
TL;DR: Circulating TT, FT, and SHBG concentrations in women are significantly heritable, underscoring the importance of further work to identify the specific genes that contribute significantly to variation in sex steroid concentrations inWomen.