Ralph Riedl

TL;DR: Using an optimized platform, the relative sensitivities of the heterozygous and homozygous deletion collections for nearly 1800 biologically active compounds are provided, providing unique insights into pathways that are sensitive and resistant to a given perturbation.

TL;DR: It is demonstrated that the chemically distinct silvestrol and synthetic rocaglamides share a common mechanism of action, which will be critical for optimization of physiologically stable derivatives and confirm the value of the ro caglamide scaffold for exploring the impact of translational modulation on disease.

TL;DR: Biochemical and genetic evidence support an overlapping binding site of 1 with the anti-cancer compound didemnin B on EF-1α, and this myxobacterial chemotype offers an interesting starting point for further investigations of the potential of therapeutics targeting elongation factor 1.

TL;DR: Biochemical analysis confirmed inhibition of protein translocation into the endoplasmic reticulum of both co- and post-translationally translocated substrates by both chemotypes, demonstrating a mechanism independent of a translating ribosome.