Ralph Krätzner
University of Göttingen
28 Papers
234 Citations
Ralph Krätzner is an academic researcher from University of Göttingen. The author has contributed to research in topics: Biology & Internal medicine. The author has an hindex of 15, co-authored 25 publications.
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Papers
Laminin-α4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells
Ralph Knöll,Ruben Postel,Jianming Wang,Ralph Krätzner,Gerrit Hennecke,Andrei M. Vacaru,Padmanabhan Vakeel,Cornelia Schubert,Kenton K. Murthy,Brinda K. Rana,Dieter Kube,Gudrun Knöll,Katrin Schäfer,Takeharu Hayashi,Torbjorn Holm,Akinori Kimura,Nicholas J. Schork,Mohammad R. Toliat,Peter Nürnberg,Heinz-Peter Schultheiss,Wolfgang Schaper,Jutta Schaper,Erik Bos,Jeroen den Hertog,Fredericus J.M. van Eeden,Peter J. Peters,Gerd Hasenfuss,Kenneth R. Chien,Jeroen Bakkers +28 more
TL;DR: This is the first report on mutations in the laminin, integrin, and ILK system in humanCardiomyopathy, which has consequences for endothelial cells as well as for cardiomyocytes, thus providing a new genetic basis for dilated carduomyopathy in humans.
216
The cystine knot of a squash-type protease inhibitor as a structural scaffold for Escherichia coli cell surface display of conformationally constrained peptides.
TL;DR: These results demonstrate that E.coli cell surface display of conformationally constrained peptides tethered to the EETI-II cystine knot scaffold has the potential to become an effective technique for the rapid isolation of small peptide molecules from combinatorial libraries that bind with high affinity to acceptor molecules.
160
Sequence Requirements of the GPNG β-Turn of the Ecballium elaterium Trypsin Inhibitor II Explored by Combinatorial Library Screening
TL;DR: Substantial amounts of misfolded byproducts were obtained upon refolding of these variants corroborating the importance of the wild type EETI-II GPNG sequence to direct quantitative formation of the cystine knot architecture.
84
Metal alkoxides as versatile precursors for group 4 phosphonates: synthesis and X-ray structure of a novel organosoluble zirconium phosphonate.
Debashis Chakraborty,Vadapalli Chandrasekhar,Manish Bhattacharjee,Ralph Krätzner,Herbert W. Roesky,Mathias Noltemeyer,Hans-Georg Schmidt +6 more
TL;DR: The compounds were characterized by 1H, 31P, and 29Si NMR, infrared (IR), and mass spectroscopic (MS) techniques and the molecular structures of 2 and 3 were confirmed by X-ray crystallography.
56
Structure of Ecballium Elaterium Trypsin Inhibitor II (Eeti-II): A Rigid Molecular Scaffold
Ralph Krätzner,Judit É. Debreczeni,Thomas Pape,Thomas R. Schneider,Alexander Wentzel,Harald Kolmar,George M. Sheldrick,Isabel Usón +7 more
TL;DR: The remarkable similarity of these structures confirms the rigidity of the molecular framework and hence its suitability as a molecular scaffold for protein-engineering purposes.