Ralph Graeser
Boehringer Ingelheim
36 Papers
353 Citations
Ralph Graeser is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Prodrug & In vivo. The author has an hindex of 19, co-authored 34 publications. Previous affiliations of Ralph Graeser include Janssen Pharmaceutica.
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Papers
Three-dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo
John A. Hickman,Ralph Graeser,Ronald de Hoogt,Suzana Vidic,Catarina Brito,Matthias Gutekunst,Heiko van der Kuip +6 more
TL;DR: These in vitro/ex vivo models represent a distinct move to capture the realities of tumor biology in situ, but significant characterization work still remains to be done in order to show that their biochemical circuitry accurately reflects that of a tumor.
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Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery
Kristin Stock,Marta Estrada,Suzana Vidic,Suzana Vidic,Suzana Vidic,Kjersti Gjerde,Kjersti Gjerde,Albin Rudisch,Vítor E. Santo,Michaël Barbier,Sami Blom,Sharath C. Arundkar,Irwin Selvam,Annika Osswald,Annika Osswald,Yan Stein,Sylvia Gruenewald,Catarina Brito,Wytske M. van Weerden,Varda Rotter,Erwin R. Boghaert,Moshe Oren,Wolfgang Sommergruber,Yolanda T. Chong,Ronald de Hoogt,Ralph Graeser +25 more
TL;DR: 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been established and cross-comparisons made using three standard cell carcinoma lines: MCF7, LNCaP, NCI-H1437 and the adaptable methodologies described here should guide the choice of appropriate simple and complex in vitro models.
Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with a poly(ethylene glycol) shell
TL;DR: Doxorubsicin polyglycerol conjugates with a high drug loading ratio showed clearly improved antitumor efficacy over doxorubicin in an ovarian xenograft tumor model (A2780) inducing transient complete remissions thus demonstrating the potential of developing efficient multifunctional dendritic drug delivery using the modular approach.
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Development of enzymatically cleavable prodrugs derived from dendritic polyglycerol.
TL;DR: The synthesis and in vitro studies of cleavable polymer-drug conjugates derived from dendritic polyglycerol and maleimide-bearing prodrugs of doxorubicin and methotrexate that are cleaved by cathepsin B are reported.
106
Development of pH-responsive core–shell nanocarriers for delivery of therapeutic and diagnostic agents
Shangjie Xu,Ying Luo,Ralph Graeser,André Warnecke,Felix Kratz,Peter Hauff,Kai Licha,Rainer Haag +7 more
TL;DR: New dendritic core-shell architectures with pH-labile linkers based on hyperbranched polyglycerol cores and biocompatible poly(ethylene glycol) shells were synthesized which encapsulate the anticancer agent doxorubicin and a dye for near-infrared imaging, an indotricarbocyanine.
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