Ralph Brandenberger
Geron Corporation
20 Papers
137 Citations
Ralph Brandenberger is an academic researcher from Geron Corporation. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 11, co-authored 20 publications. Previous affiliations of Ralph Brandenberger include National Institutes of Health.
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Papers
Differences between human and mouse embryonic stem cells.
Irene Ginis,Yongquan Luo,Takumi Miura,Scott R. Thies,Ralph Brandenberger,Sharon Gerecht-Nir,Michal Amit,Ahmet Hoke,Melissa K. Carpenter,Joseph Itskovitz-Eldor,Mahendra S. Rao +10 more
TL;DR: The profile of gene expression observed in H1 cells was similar to that of two other human ES cell lines tested, indicating that the observed differences between human and mouse ES cells were species-specific rather than arising from differences in culture conditions.
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Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells
Zara Melkoumian,Jennifer L. Weber,David M. Weber,Andrei Gennadyevich Fadeev,Yue Zhou,Paula Dolley-Sonneville,Jiwei Yang,Liqun Qiu,Catherine A. Priest,Christopher B. Shogbon,Arthur W. Martin,Jodelle Karen Nelson,Peter West,James P. Beltzer,Santona Pal,Ralph Brandenberger +15 more
TL;DR: Synthetic peptide-acrylate surfaces (PAS) are described that support self-renewal of hESCs in chemically defined, xeno-free medium and cell morphology and phenotypic marker expression were similar for cells cultured on PAS or Matrigel.
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MPSS profiling of human embryonic stem cells.
Ralph Brandenberger,Irina Khrebtukova,R. Scott Thies,Takumi Miura,Cai Jingli,Raj K. Puri,Thomas J. Vasicek,Jane S. Lebkowski,Mahendra S. Rao,Mahendra S. Rao +9 more
TL;DR: This analysis provides a molecular signature of genes expressed by undifferentiated ES cells that can be used to monitor the state of ES cells isolated by different laboratories using independent methods and maintained under differing culture conditions.
Monitoring early differentiation events in human embryonic stem cells by massively parallel signature sequencing and expressed sequence tag scan.
Takumi Miura,Yongquan Luo,Irina Khrebtukova,Ralph Brandenberger,Daixing Zhou,R. Scott Thies,Tom Vasicek,Holly Y. Young,Jane S. Lebkowski,Melissa K. Carpenter,Mahendra S. Rao +10 more
TL;DR: To identify genes that may be involved in the process of human embryonic stem cell (hESC) differentiation, gene expression was profiled by expressed sequenced tag (EST) enumeration and massively parallel signature sequencing (MPSS) using RNA samples from feeder-free cultures of undifferentiated and differentiated H1, H7, and H9 lines.
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Patent
Genes that are up- or down-regulated during differentiation of human embryonic stem cells
Ralph Brandenberger,Elisa Brunette,Joseph D. Gold,John M. Irving,Ramkumar Mandalam,Michael Mok,Sandra Powell,Dawne Shelton,Lawrence W. Stanton +8 more
- 13 Mar 2004
TL;DR: In this paper, the expression profiles of 35,000 unique transcripts have been amplified and sequenced from undifferentiated human embryonic stem cells and three types of differentiated progeny, and statistical analysis of the assembled transcripts identified genes that alter expression levels as differentiation proceeds.
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