Ralph A. Rivero
Johnson & Johnson Pharmaceutical Research and Development
8 Papers
125 Citations
Ralph A. Rivero is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Motilin & Motilin receptor. The author has an hindex of 4, co-authored 8 publications. Previous affiliations of Ralph A. Rivero include Johnson & Johnson.
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Papers
2,3-Diaryl-5-anilino[1,2,4]thiadiazoles as melanocortin MC4 receptor agonists and their effects on feeding behavior in rats.
Kevin Pan,Malcolm K. Scott,Daniel H. S. Lee,Louis J. Fitzpatrick,Jeffery J Crooke,Ralph A. Rivero,Daniel I. Rosenthal,Anil H. Vaidya,Zhao Boyu,Allen B. Reitz +9 more
TL;DR: 2,3-diaryl-5-anilino[1,2,4]thiadiazoles 3 as potent and selective MC4 receptor agonists are discovered and SAR development on the three attached aryl rings improved the binding affinity from 174 nM to 4.4 nM IC(50).
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Patent
Substituted diamine derivatives useful as motilin antagonists
TL;DR: In this paper, substituted diamine derivatives for the formula (I) were described, and motilin receptor antagonists were used for the treatment of associated conditions and disorders such as gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel syndrome.
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Synthesis and structure–activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor
TL;DR: The preparation of novel pyridyl ethers as ligands for the nicotinic acetylcholine receptor (nAChR) is described and Variations of the ring size of the azacycle and substitution on the pyridine had dramatic effects on receptor binding affinity with IC50s at the alpha4beta2 nA ChR.
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Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin.
Matthews Jay M,Fina Liotta,William Hageman,Ralph A. Rivero,Lori Westover,Maria Yang,Jun Xu,Keith T. Demarest +7 more
TL;DR: The use of a multiplex mimetic assay led to the identification of 1,4-dihydropyrimidines with potent and selective calcitonin receptor mimetic activity, which were efficacious in a neonatal mouse calvaria in vitro model.
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Discovery of a Dihydropyrimidine Series of Molecules that Selectively Mimic the Biological Actions of Calcitonin.
Matthews Jay M,Fina Liotta,William Hageman,Ralph A. Rivero,Lori Westover,Maria Yang,Jun Xu,Keith T. Demarest +7 more
TL;DR: In this paper, the use of a multiplex mimetic assay led to identify 1,4-dihydropyrimidines with potent and selective calcitonin receptor mimetic activity.
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