Ralf P. Brandes
Goethe University Frankfurt
306 Papers
2.4K Citations
Ralf P. Brandes is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: NADPH oxidase & Biology. The author has an hindex of 77, co-authored 271 publications. Previous affiliations of Ralf P. Brandes include University of California, San Francisco & University of Würzburg.
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Papers
Increased Nitrovasodilator Sensitivity in Endothelial Nitric Oxide Synthase Knockout Mice: Role of Soluble Guanylyl Cyclase
Ralf P. Brandes,Do-yei Kim,Friedrich-Hubertus Schmitz-Winnenthal,Mojgan Amidi,Axel Gödecke,Alexander Mülsch,Rudi Busse +6 more
TL;DR: Both the acute cessation of endothelial NO formation in WT mice and the chronic deficiency of NO in eNOS(-/-) mice restore the NO sensitivity of sGC and enhance vascular smooth muscle relaxation in response to nitrovasodilator agents.
Anatomic heterogeneity of vascular aging: role of nitric oxide and endothelin.
Matthias Barton,Francesco Cosentino,Ralf P. Brandes,Pierre Moreau,Sidney Shaw,Thomas F. Lüscher +5 more
TL;DR: Vascular function was impaired in the aorta but not the femoral artery, which may be related to lower eNOS mRNA expression and SOD activity.
Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide
Eckhart Büssemaker,Frank Pistrosch,Sarah Förster,Kay Herbrig,Peter Gross,Jens Passauer,Ralf P. Brandes +6 more
TL;DR: In this paper, the role of the Rho-associated kinase (ROK) for the regulation of FBF and unmask a potential role of ROK for the regulatory of endothelium-derived nitric oxi...
First evidence for a crosstalk between mitochondrial and NADPH oxidase-derived reactive oxygen species in nitroglycerin-triggered vascular dysfunction.
Philip Wenzel,Hanke Mollnau,Matthias Oelze,Eberhard Schulz,Jennifer M. Dias Wickramanayake,Johanna Müller,Swenja Schuhmacher,Marcus Hortmann,Stephan Baldus,Tommaso Gori,Ralf P. Brandes,Thomas Münzel,Andreas Daiber +12 more
TL;DR: A crosstalk between mitochondrial and Nox-derived ROS with distinct mechanistic effects and sites for pharmacological intervention is suggested, suggesting a role of mitochondria for nitrate tolerance development.
NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis
Claudia Goettsch,Andrea Babelova,Olivia Trummer,Reinhold G. Erben,Martina Rauner,Stefan Rammelt,Norbert Weissmann,Valeska Weinberger,Sebastian Benkhoff,Marian Kampschulte,Barbara Obermayer-Pietsch,Lorenz C. Hofbauer,Ralf P. Brandes,Katrin Schröder +13 more
TL;DR: In an in vivo model of murine ovariectomy–induced osteoporosis, pharmacological inhibition or acute genetic knockdown of Nox4 mitigated loss of trabecular bone and represents a potential therapeutic target for the treatment of osteop orosis.