Ralf P. Brandes
Goethe University Frankfurt
306 Papers
2.4K Citations
Ralf P. Brandes is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: NADPH oxidase & Biology. The author has an hindex of 77, co-authored 271 publications. Previous affiliations of Ralf P. Brandes include University of California, San Francisco & University of Würzburg.
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Papers
Evidence Against a Role for NADPH Oxidase Modulating Hepatic Vascular Tone in Cirrhosis
Jorge Gracia–Sancho,Bàrbara Laviña,Aina Rodríguez–Vilarrupla,Ralf P. Brandes,Mercedes Fernandez,Jaume Bosch,Joan–Carles García–Pagán +6 more
TL;DR: The study shows that NADPH-oxidase activity is decreased in the cirrhotic livers and therefore cannot explain increased hepatic O(2)(-), endothelial dysfunction, and increased vascular tone in cirrhosis.
Composition and Functions of Vascular Nicotinamide Adenine Dinucleotide Phosphate Oxidases
Ralf P. Brandes,Katrin Schröder +1 more
TL;DR: Positive and negative vascular effects of ROS, such as endothelial dysfunction, vascular hypertrophy, aneurysm formation, and inflammatory activation, appear to be the consequence of an activation of Nox1 and Nox2.
Targeting Inflammation and Oxidative Stress in Atrial Fibrillation: Role of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibition with Statins
TL;DR: Evidence indicates that statins prevent AF-induced electrical remodeling in animal models of atrial tachypacing and may reduce the new onset of AF after cardiac surgery.
Direct detection of reactive oxygen species ex vivo
TL;DR: A brief review on the most frequently used techniques to assess oxygen-derived free radical generation in isolated tissue preparations and cells and the shortcomings associated with current techniques are provided.
Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice
Norbert Weissmann,Akylbek Sydykov,Hermann Kalwa,Hermann Kalwa,Ursula Storch,Beate Fuchs,Michael Mederos y Schnitzler,Ralf P. Brandes,Friedrich Grimminger,Marcel Meissner,Marc Freichel,Stefan Offermanns,Florian Veit,Oleg Pak,Karl-Heinz Krause,Ralph T. Schermuly,Alison C. Brewer,Harald H.H.W. Schmidt,Werner Seeger,Ajay M. Shah,Thomas Gudermann,Hossein Ardeschir Ghofrani,Alexander Dietrich +22 more
TL;DR: A novel mechanistic model comprising endothelial Nox2-derived production of superoxide, activation of phospholipase C-γ, inhibition of diacylglycerol (DAG) kinase, DAG-mediated activation of TRPC6 and ensuing LIRE is supported by pharmacological and molecular evidence.