Ralf P. Brandes
Goethe University Frankfurt
306 Papers
2.4K Citations
Ralf P. Brandes is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: NADPH oxidase & Biology. The author has an hindex of 77, co-authored 271 publications. Previous affiliations of Ralf P. Brandes include University of California, San Francisco & University of Würzburg.
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Papers
Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability.
Lisa K. Sha,Weixiao Sha,Laura Kuchler,Andreas Daiber,Annika Klara Giegerich,Andreas Weigert,Tilo Knape,Ryan G. Snodgrass,Katrin Schröder,Ralf P. Brandes,Bernhard Brüne,Andreas von Knethen +11 more
TL;DR: It is demonstrated that reduced levels of GCLM as well as xCT in Nrf2(-/-) BMDMΦ limit GSH availability, thereby inhibiting antigen-induced CD8(+) T cell function.
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Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery.
Eckhart Büssemaker,Rüdiger Popp,Beate Fisslthaler,C.M. Larson,Ingrid Fleming,Rudi Busse,Ralf P. Brandes +6 more
TL;DR: It is indicated that short-term treatment with T3 increases endothelium-dependent relaxation, most probably by increasing vascular cyclic AMP content.
PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow.
Takao Hikita,Fatemeh Mirzapourshafiyi,Pedro Barbacena,Meghan Riddell,Ayesha Pasha,Mengnan Li,Takuji Kawamura,Ralf P. Brandes,Tomonori Hirose,Shigeo Ohno,Holger Gerhardt,Michiyuki Matsuda,Claudio A. Franco,Masanori Nakayama +13 more
TL;DR: It is shown that flow‐induced spatial distribution of PAR‐3/aP KCλ and aPKCλ/GSK3β complexes controls local GSK3β activity and thereby regulates endothelial planar polarity, and shed light on a novel relationship between endothelial polarity and vascular homeostasis highlighting avenues for novel therapeutic strategies.
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Endo-PDI is required for TNFα-induced angiogenesis
Livia L Camargo,Andrea Babelova,Anja Mieth,Andreas Weigert,Juliane Mooz,Krishnaraj Rajalingam,Heinrich Heide,Ilka Wittig,Lucia Rossetti Lopes,Ralf P. Brandes +9 more
TL;DR: Endo-PDI is established as a novel, important mediator of AP-1-driven gene expression and endothelial angiogenic function.
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Laminar shear stress regulates mitochondrial dynamics, bioenergetics responses and PRX3 activation in endothelial cells
Rosa Bretón-Romero,Rebeca Acín-Pérez,Fernando Rodríguez-Pascual,María Martínez-Molledo,Ralf P. Brandes,Eduardo Rial,José Antonio Enríquez,Santiago Lamas +7 more
TL;DR: The data support a novel and active role for mitochondria in endothelial cells as active players, able to transduce the mechanical force of shear stress in the vascular endothelium into a biological response.
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