Ralf Kist
Newcastle University
44 Papers
185 Citations
Ralf Kist is an academic researcher from Newcastle University. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 21, co-authored 43 publications. Previous affiliations of Ralf Kist include Centre for Life & University of Freiburg.
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Papers
SOX9 is required for maintenance of the pancreatic progenitor cell pool
Philip A. Seymour,Kristine K. Freude,Man N. Tran,Erin Mayes,Jan Jensen,Ralf Kist,Gerd Scherer,Maike Sander,Maike Sander +8 more
TL;DR: It is shown that Sox9 maintains pancreatic progenitors by stimulating their proliferation, survival, and persistence in an undifferentiated state, and the finding that SOX9 regulates the Notch-effector HES1 suggests a NotCh-dependent mechanism and establishes a possible genetic link between SOX factors and Notch.
606
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium
Pauline Bastide,Charbel Darido,Julie Pannequin,Ralf Kist,Sylvie Robine,Christiane Marty-Double,Frédéric Bibeau,Gerd Scherer,Dominique Joubert,Frédéric Hollande,Philippe Blache,Philippe Jay +11 more
TL;DR: The inactivation of Sox9 affected differentiation throughout the intestinal epithelium, with a disappearance of Paneth cells and a decrease of the goblet cell lineage, and the morphology of the colon epithelia was severely altered.
Homozygous Inactivation of Sox9 Causes Complete XY Sex Reversal in Mice
Francisco J. Barrionuevo,Stefan Bagheri-Fam,Jürgen Klattig,Ralf Kist,Ralf Kist,Makoto Mark Taketo,Christoph Englert,Gerd Scherer +7 more
TL;DR: In vivo proof that, in contrast to the situation in humans, complete XY sex reversal in mice requires inactivation of both Sox9 alleles and that Sox9 is essential for testogenesis in mice is provided.
Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament.
Yuki Sugimoto,Aki Takimoto,Haruhiko Akiyama,Ralf Kist,Gerd Scherer,Takashi Nakamura,Yuji Hiraki,Chisa Shukunami +7 more
TL;DR: The Scx+/Sox9+ progenitor pool is a unique multipotent cell population that gives rise to tenocytes, ligamentocytes and chondrocytes for the establishment of the chONDro-tendinous/ligamentous junction.
267
Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development.
TL;DR: The data indicate that Sox9 is required for early and late stages of valvulogenesis and identify a potential role for Sox9 in valve disease mechanisms.
187