Rakhee Banerjee
Case Western Reserve University
18 Papers
1 Citations
Rakhee Banerjee is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 6, co-authored 6 publications.
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Papers
Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance
TL;DR: Heterozygous mutations in two core subunits of Polycomb Repressive Complex 2 (PRC2), the histone H3 lysine 27 (H3K27)-specific methyltransferase E(Z) and its partner, the H3 binding protein ESC, increase longevity and reduce adult levels of trimethylated H3K26me3 are reported.
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Histone Demethylase UTX and Chromatin Remodeler BRM Bind Directly to CBP and Modulate Acetylation of Histone H3 Lysine 27
TL;DR: It is proposed that direct binding of UTX and BRM to CBP and their modulation of H3K27ac play an important role in antagonizing Polycomb silencing.
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Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.
TL;DR: It is reported here that PC inhibits the histone acetyltransferase (HAT) activity of CREB-binding protein (CBP), suggesting that PC/PRC1 inhibition of CBP HAT activity plays a role in regulating transcription of both repressed and active PC-regulated genes.
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MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis
William J. Massey,Venkateshwari Varadharajan,Rakhee Banerjee,Amanda L. Brown,Anthony J. Horak,Rachel C. Hohe,Bryan M. Jung,Yunguang Qiu,Ernest R. Chan,Calvin Pan,Renliang Zhang,Daniel Allende,Belinda Willard,Feixiong Cheng,Aldons J. Lusis,Mark Brown +15 more
TL;DR: In this paper , the authors showed that MBOAT7 function in adipocytes contributes to diet-induced metabolic disturbances including hyperinsulinemia and systemic insulin resistance, and found that adipocyte-specific genetic deletion of Mboat7 is sufficient to promote hyperinulinemia and mild fatty liver.
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Metaorganismal choline metabolism shapes olfactory perception.
William V. Massey,Kristen E Kay,Thomas C. Jaramillo,Anthony J. Horak,Shijie Cao,Lucas J Osborn,Rakhee Banerjee,M. Mrdjen,Michael K. Hamoudi,Daniel J. Silver,Amy C. Burrows,Amanda L. Brown,Ofer Reizes,Justin D. Lathia,Zeneng Wang,S. L. Hazen,J. M. Brown +16 more
TL;DR: Reducing TMAO levels by inhibiting gut microbe-driven choline conversion to trimethylamine (TMA), and then performing comprehensive behavioral phenotyping in mice demonstrates a previously underappreciated role for the T MAO pathway in olfactory-related behaviors.
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