Rainer Alex
Hoffmann-La Roche
8 Papers
Rainer Alex is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Peptide & Globular protein. The author has an hindex of 7, co-authored 8 publications.
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Papers
Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monolayers.
TL;DR: Sassinavir and ritonavir are both substrates for an efflux mechanism in the gut, most likely P-glycoprotein, which acts as a counter-transporter for both drugs, which may partially account for the low and variable oral bioavailability of saquinavir in clinical studies and for its increased bioavailability after co-administration with ritonvir.
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Preparation of medicines for children – A hierarchy of classification
Terry B. Ernest,Jo Craig,Anthony J Nunn,Smita Salunke,Catherine Tuleu,Joerg Breitkreutz,Rainer Alex,John Hempenstall +7 more
TL;DR: Compounding and manipulation of medicines in relation to approval by medicines regulators and non-approved preparation to fulfil the needs of the individual patient are explored.
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The molecular basis for the prolonged blood circulation of lipidated incretin peptides: Peptide oligomerization or binding to serum albumin?
Ying Wang,Aleksey Lomakin,Sonoko Kanai,Rainer Alex,Sara Belli,Massimiliano Donzelli,George B. Benedek +6 more
TL;DR: It is shown that lipid conjugated forms of a GLP-1/GIP/glucagon hybrid peptides stay in circulation for hours and it is suggested that the monomeric lipidated peptides bind to HSA mainly by the fatty acid chain.
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Evaluation of bovine milk extracellular vesicles for the delivery of locked nucleic acid antisense oligonucleotides.
Philip Grossen,Michaela Portmann,Erich Koller,Martina Brigitte Duschmalé,Tanja Minz,Sabine Sewing,Nikhil J. Pandya,Sabine Kux van Geijtenbeek,Axel Ducret,Eric-André Kusznir,Sylwia Huber,Marco Berrera,Matthias E. Lauer,Philippe Ringler,Bettina Nordbo,Marianne Lerbech Jensen,Filippo Sladojevich,Ravi Jagasia,Rainer Alex,Remo Gamboni,Michael Keller +20 more
TL;DR: BMEVs were investigated for their potential to shuttle locked nucleic acid-modified antisense oligonucleotides (LNA ASOs) into the systemic circulation after oral administration and it was found that additional purification by density gradients efficiently reduced levels of non-EV associated proteins.
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Process and scaling parameters for wet media milling in early phase drug development: A knowledge based approach.
TL;DR: It is shown, that the milling kinetics can be fairly well predicted for a wide range of these operating parameters, and may therefore be useful for rational process planning and scale‐up considerations in the industrial setting.
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