Raimund Eck
Leibniz Association
19 Papers
201 Citations
Raimund Eck is an academic researcher from Leibniz Association. The author has contributed to research in topics: Candida albicans & Mutant. The author has an hindex of 13, co-authored 19 publications.
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Papers
The Yeast Candida albicans Binds Complement Regulators Factor H and FHL-1
Taru Meri,Andrea Hartmann,D. Lenk,Raimund Eck,R. Würzner,Jens Hellwage,Seppo Meri,Peter F. Zipfel +7 more
TL;DR: Data indicate that by surface acquisition of host complement regulators, the human pathogenic yeast C. albicans is able to regulate alternative complement activation at its surface and to inactivate toxic complement activation products.
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Gpm1p is a factor H-, FHL-1-, and plasminogen-binding surface protein of Candida albicans.
Sophia Poltermann,Anja Kunert,Monika von der Heide,Raimund Eck,Andrea Hartmann,Peter F. Zipfel,Peter F. Zipfel +6 more
TL;DR: The surface-expressed CaGpm1p is a virulence factor that utilizes the host Factor H, FHL-1, and plasminogen for immune evasion and degradation of extracellular matrices.
140
A multicopper oxidase gene from Candida albicans: cloning, characterization and disruption.
TL;DR: The null mutant strain showed no change in pathogenicity compared with the wild-type strain in the mouse model of systemic candidiasis and the deduced amino acid sequences of CaFET3 and the Saccharomyces cerevisiae FET3 gene are 55%.
111
The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence.
Sophia Poltermann,Monika Nguyen,Juliane Günther,Jürgen Wendland,Jürgen Wendland,Albert Härtl,Waldemar Künkel,Peter F. Zipfel,Raimund Eck +8 more
TL;DR: The V-ATPase subunit Vma7p is involved in vacuolar ion transport and this transport is required for hyphal growth and virulence of C. albicans, which results in reduced vacuole acidification and defects in degradation of intravacuolar putative endosomal structures.
53
A phosphatidylinositol 3-kinase of Candida albicans influences adhesion, filamentous growth and virulence.
TL;DR: The results suggest that CaVPS34 may serve as a potential target for antifungal drugs as it was shown to be avirulent in a mouse model of systemic infection.
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