Rahul D. Shingare
National Chemical Laboratory
18 Papers
49 Citations
Rahul D. Shingare is an academic researcher from National Chemical Laboratory. The author has contributed to research in topics: Total synthesis & Chemistry. The author has an hindex of 4, co-authored 14 publications. Previous affiliations of Rahul D. Shingare include University of California, Santa Cruz & Academy of Scientific and Innovative Research.
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Papers
Repurposing of a drug scaffold: Identification of novel sila analogues of rimonabant as potent antitubercular agents.
Remya Ramesh,Rahul D. Shingare,Vinod Kumar,Amitesh Anand,Swetha B,Sridhar Veeraraghavan,Srikant Viswanadha,Ramesh Ummanni,Rajesh S. Gokhale,D. Srinivasa Reddy,D. Srinivasa Reddy +10 more
TL;DR: The sila analogue 18a was found to be the most potent antimycobacterial compound from this series with an excellent selectivity index and further optimization resulted in new compounds with significant improvement in anti-tubercular activity against Mycobacterium tuberculosis (H37Rv).
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First total synthesis of hunanamycin A.
TL;DR: The present effort provides access to sufficient amounts of scarce hunanamycin A for further biological evaluation and confirmation of the assigned absolute configuration, and four new analogues of the natural product are reported.
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A General Approach to N‐Heterocyclic Carbenes with a Fused Tetracyclic Core: Ligands for Suzuki–Miyaura Cross‐Coupling Reaction
Revannath L. Sutar,Vinod Kumar,Rahul D. Shingare,Shridhar H. Thorat,Rajesh G. Gonnade,D. Srinivasa Reddy +5 more
TL;DR: In this paper, the synthesis of an N-heterocyclic carbene (NHC) based on a tetracyclic scaffold by using simple, general, and scalable chemistry is disclosed.
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Synthesis and Investigation of the Abiotic Formation of Pyonitrins A-D
TL;DR: This work has accomplished the first biomimetic total synthesis of pyonitrins A–D in three steps and studied the nonenzymatic formation of the pyon itrins using 15N NMR spectroscopy.
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Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology
TL;DR: In this paper, a review discusses discovery strategies that successfully identified a wide range of inhibitors and the processes used to characterize their inhibition mechanism and further improvement, and examine the structure-activity relationship (SAR) for some of these inhibitors to optimize inhibitor activity.
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