Raffaella Melfi
University of Geneva
15 Papers
32 Citations
Raffaella Melfi is an academic researcher from University of Geneva. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 3 publications.
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Papers
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.
TL;DR: Histone H3 methylated in vitro by the E(Z)/ESC complex binds specifically to Polycomb protein, which is closely associated with Polycomb binding sites on polytene chromosomes but is also found in centric heterochromatin, chromosome 4, and telomeric sites.
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Establishment of Polycomb silencing requires a transient interaction between PC and ESC
TL;DR: It is shown that PC and ESC can establish silencing of a reporter gene but that each requires the presence of the other.
Assembly of Polycomb complexes and silencing mechanisms.
TL;DR: The action of these complexes and of Trithorax complexes bound to the Polycomb Response Element establish alternative silent or derepressed states that are remembered through cell division and maintained for the rest of development.
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Impact of Heavy Metals in Eggs and Tissues of C. caretta along the Sicilian Coast (Mediterranean Sea)
Dario Savoca,Marco Arculeo,Vincenzo Arizza,Andrea Pace,Raffaella Melfi,Santo Caracappa,Giulia Caracappa,Cecilia Vullo,Irene Cambera,Giulia Visconti,Vittoria Giudice,Gaetano D’Oca,Salvatore Dipl Ing Messina,Antonella Maccotta +13 more
TL;DR: In this paper , the authors compared the heavy metal concentration found in different tissues and eggs of the loggerhead sea turtle and evaluated the potential ecotoxicological risk for this important species and highlighted the importance of multi-element biomonitoring by increasing knowledge on the biodistribution of 18 heavy metals and the related potential risks for C. caretta.
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation.
Federica Corrao,Maria Grazia Zizzo,Marco Tutone,Raffaella Melfi,I. Fiduccia,Pietro Salvatore Carollo,Aldo Di Leonardo,Gaetano Felice Caldara,Riccardo Perriera,Andrea Pace,Beatrice Belmonte,Selene Sammataro,Ivana Pibiri,Laura Lentini +13 more
TL;DR: In this article , an acute toxicological study for the three TRIDs was conducted in vivo on mice, according to the OECD No.420 guidelines, animals were divided into groups and treated with a single dose of TRIDs molecules or Ataluren, an FDA-approved TRID molecule, as control.
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