Raffaella Macchi
University of Milan
9 Papers
21 Citations
Raffaella Macchi is an academic researcher from University of Milan. The author has contributed to research in topics: Gene & Pseudomonas aeruginosa. The author has an hindex of 8, co-authored 9 publications.
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Papers
Characterization of the last step of the aerobic phenylacetic acid degradation pathway.
Juan Nogales,Raffaella Macchi,Federico Franchi,Dagania Barzaghi,Cristina Fernández,José Luis García,Giovanni Bertoni,Eduardo Díaz +7 more
TL;DR: It is shown here that succinyl-CoA is one of the final products of this pathway in Pseudomonas putida and Escherichia coli and in vivo and in vitro studies revealed that the paaE gene encodes the beta-ketoadipyl- CoA thiolase that catalyses the last step of the PA catabolic pathway.
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From Food Waste to Innovative Biomaterial: Sea Urchin-Derived Collagen for Applications in Skin Regenerative Medicine.
C. Ferrario,Francesco Rusconi,Albana Pulaj,Raffaella Macchi,Paolo Landini,Moira Paroni,Graziano Colombo,Tiziana Martinello,Luca Melotti,Chiara Gomiero,M. Daniela Candia Carnevali,Francesco Bonasoro,Marco Vincenzo Patruno,Michela Sugni +13 more
TL;DR: The common marine invertebrate sea urchin represents a promising and eco-friendly source of native collagen to develop innovative CBSS for skin injury treatment, which is mechanically stable in wet conditions, biocompatible in vitro, and efficiently acts as a scaffold for fibroblast infiltration.
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The small RNA ReaL: a novel regulatory element embedded in the Pseudomonas aeruginosa quorum sensing networks.
TL;DR: The results indicate that ReaL contributes to P. aeruginosa virulence and is negatively regulated by the las regulator LasR and impacts positively the synthesis of the pqs quinolone signal PQS by a positive post-transcriptional effect on the pqC gene.
31
The PAPI-1 pathogenicity island-encoded small RNA PesA influences Pseudomonas aeruginosa virulence and modulates pyocin S3 production
Silvia Ferrara,Marilena Falcone,Raffaella Macchi,Alessandra Bragonzi,Daniela Girelli,Lisa Cariani,Cristina Cigana,Giovanni Bertoni +7 more
TL;DR: Interestingly, the deletion of pesA gene results in increased sensitivity to UV irradiation and to the fluoroquinolone antibiotic ciprofloxacin, which suggests an involvement of pyocin S3 in DNA damage repair and a regulatory role of PesA on this function.
A shotgun antisense approach to the identification of novel essential genes in Pseudomonas aeruginosa
TL;DR: Interestingly, the essential genes in this panel were suggested to take part in a broader range of cellular functions than those currently targeted by extant antibiotics, namely protein secretion, biosynthesis of cofactors, prosthetic groups and carriers, energy metabolism, central intermediary metabolism, transport of small molecules, translation, post-translational modification, non-ribosomal peptide synthesis, lipopolysaccharide synthesis/modification, and transcription regulation.