Rafeah Alam
Babraham Institute
3 Papers
1 Citations
Rafeah Alam is an academic researcher from Babraham Institute. The author has contributed to research in topics: Streptococcus pneumoniae & Immune system. The author has an hindex of 2, co-authored 3 publications. Previous affiliations of Rafeah Alam include University of Cambridge.
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Papers
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.
Anne-Katrien Stark,Anita Chandra,Krishnendu Chakraborty,Rafeah Alam,Valentina Carbonaro,Jonathan Clark,Srividya Sriskantharajah,Glyn Bradley,Alex G. Richter,Edward Banham-Hall,Menna R. Clatworthy,Sergey Nejentsev,J. Nicole Hamblin,Edith M. Hessel,Alison M. Condliffe,Klaus Okkenhaug +15 more
TL;DR: Hyper-activation of PI3Kδ promotes development of a subset of B cells that exacerbate infection in an antibody-independent manner and can be reversed by therapeutic targeting in vivo, suggesting a potential therapeutic target.
Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure
Albert Kwok,Ilona Zvetkova,Samuel Virtue,Ineke Luijten,Isabel Huang-Doran,Patsy Tomlinson,David A Bulger,James A. West,Steven A. Murfitt,Julian L. Griffin,Rafeah Alam,Daniel Hart,Rachel G. Knox,Peter J. Voshol,Antonio Vidal-Puig,Jørgen Arendt Jensen,Stephen O'Rahilly,Robert K. Semple,Robert K. Semple,Robert K. Semple +19 more
TL;DR: Pik3r1 dysfunction in mice phenocopies the IR and reduced adiposity may not reflect bona fide lipodystrophy, but rather, increased energy expenditure, and it is suggested that further study of brown adipose tissue in both humans and mice is warranted.
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PI3Kδ hyper-activation promotes the development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
Anne-Katrien Stark,Anita Chandra,Krishnendu Chakraborty,Rafeah Alam,Valentina Carbonaro,Jonathan Clark,Srividya Sriskantharajah,Glyn Bradley,Alex G. Richter,Edward Banham-Hall,Menna R. Clatworthy,Sergey Nejentsev,J. Nicole Hamblin,Edith M. Hessel,Alison M. Condliffe,Klaus Okkenhaug +15 more
TL;DR: It is shown that an inhaled PI3Kδ inhibitor improves survival rates following S. pneumoniae infection in wild-type mice and in mice with activated PI3 kδ, suggesting that a subset of B cells in the lung can promote the severity of S. tuberculosis infection.