Radha Karki
Yeungnam University
29 Papers
276 Citations
Radha Karki is an academic researcher from Yeungnam University. The author has contributed to research in topics: Topoisomerase & Structure–activity relationship. The author has an hindex of 18, co-authored 29 publications. Previous affiliations of Radha Karki include University of Kansas & University of Oklahoma Health Sciences Center.
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Papers
Retinoic acid signaling pathways in development and diseases.
Bhaskar C. Das,Pritam Thapa,Radha Karki,Sasmita Das,Sweta Mahapatra,Ting Chun Liu,Ingrid Torregroza,Darren P. Wallace,Suman Kambhampati,Peter J. Van Veldhuizen,Amit Verma,Swapan K. Ray,Todd Evans +12 more
TL;DR: A broad overview on the importance of retinoids in development and various diseases is provided, highlighting various retinoidal in the drug discovery process, ranging all the way from retinoid chemistry to clinical uses and imaging.
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Boron chemicals in diagnosis and therapeutics
Bhaskar C. Das,Pritam Thapa,Radha Karki,Caroline Schinke,Sasmita Das,Suman Kambhampati,Suman Kambhampati,Sushanta K. Banerjee,Sushanta K. Banerjee,Peter J. Van Veldhuizen,Peter J. Van Veldhuizen,Amit Verma,Louis M. Weiss,Todd Evans +13 more
TL;DR: It is expected that in the near future, several boron-containing drugs should become available in the market with better efficacy and potency than existing drugs.
Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities.
Jong-Keun Son,Long-Xuan Zhao,Arjun Basnet,Pritam Thapa,Radha Karki,Younghwa Na,Yurngdong Jahng,Tae Cheon Jeong,Byeong-Seon Jeong,Chong-Soon Lee,Eung-Seok Lee +10 more
TL;DR: From the structure-activity relationships, it is concluded that the number of aryl groups employed would be critical for their biological activities in novel antitumor agents.
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A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases.
Han Byeol Kwon,Chanmi Park,Kyung Hwa Jeon,Eunyoung Lee,So Eun Park,Kyu Yeon Jun,Tara Man Kadayat,Pritam Thapa,Radha Karki,Younghwa Na,Mi Sun Park,Seung Bae Rho,Eung-Seok Lee,Youngjoo Kwon +13 more
TL;DR: The modification of compounds 8 and 22 with the introduction of a methoxy instead of a hydroxy group enhanced endogenous topo inhibitory activity, metabolic stability in diverse types of liver microsomes and improved pharmacokinetic parameters in rat plasma such as augmentation of bioavailability.
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Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship study
Radha Karki,Pritam Thapa,Han Young Yoo,Tara Man Kadayat,Pil Hoon Park,Youngwha Na,Eunyoung Lee,Kyung Hwa Jeon,Won-Jea Cho,Heesung Choi,Youngjoo Kwon,Eung-Seok Lee +11 more
TL;DR: The concrete structure-activity relationship was observed that dihydroxylated 2,4,6-triphenyl pyridines with hydroxyl group at meta or para position of 2-phenyl ring displayed significant topoisomerase II inhibitory activity as well as cytotoxicity.
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