Rachel Levy-Toledano
National Institutes of Health
12 Papers
153 Citations
Rachel Levy-Toledano is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Insulin receptor & Insulin receptor substrate. The author has an hindex of 10, co-authored 12 publications.
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Papers
Mutations in the insulin receptor gene.
Simeon I. Taylor,Alessandro Cama,Domenico Accili,Fabrizio Barbetti,Michael J. Quon,Maria de la Luz Sierra,Yoshifumi Suzuki,Elizabeth Roller,Rachel Levy-Toledano,Efrat Wertheimer,Victoria Y. Moncadaj,Hiroko Kadowaki,Takashi Kadowaki +12 more
TL;DR: This review describes mutations in the insulin receptor gene that have been identified in patients with genetic forms of insulin resistance and indicates that identification of these mutations has elucidated the molecular mechanisms that cause disease in these patients.
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Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells.
TL;DR: By binding directly to p85, the phosphorylated YHTM motif in the COOH terminus of the insulin receptor contributes partially to mediating the effect of insulin to activate PI 3-kinase.
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Structural basis by which a recessive mutation in the alpha-subunit of the insulin receptor affects insulin binding.
TL;DR: It is demonstrated that the Leu323-delta 43 hybrid receptor binds insulin with high affinity, and that the hybrid receptor can phosphorylate insulin receptor substrate-1 (IRS-1) in response to insulin and can be coimmunoprecipitated together with IRS-1 by anti-IRs-1 antibody.
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Mutations in the insulin receptor gene in patients with genetic syndromes of insulin resistance and acanthosis nigricans.
Domenico Accili,Fabrizio Barbetti,Alessandro Cama,Hiroko Kadowaki,Takashi Kadowaki,Eiichi Imano,Rachel Levy-Toledano,Simeon I. Taylor +7 more
TL;DR: Mutations of the insulin receptor gene have been identified in patients with genetic syndromes of insulin resistance associated with acanthosis nigricans, and studies of mutant receptors expressed in transfection systems have contributed to the understanding of the structure-function relationships ofThe insulin receptor.
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Paradoxical biological effects of overexpressed insulin-like growth factor-1 receptors in chinese hamster ovary cells
Hisanori Kato,Teresa N. Faria,Bethel Stannard,Rachel Levy-Toledano,Simeon I. Taylor,Charles T. Roberts,Derek LeRoith +6 more
TL;DR: The data suggest that IGF‐I and insulin signal pathways may differ in CHO cells, and that there may even be divergent IGF-I signaling pathways for short vs. long‐term effects.
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