Rachel E. Ellsworth
Windber Research Institute
19 Papers
322 Citations
Rachel E. Ellsworth is an academic researcher from Windber Research Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 12, co-authored 19 publications.
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Papers
Outer breast quadrants demonstrate increased levels of genomic instability.
Darrell L. Ellsworth,Rachel E. Ellsworth,Brad Love,Brenda Deyarmin,Susan M. Lubert,Vimal Mittal,Jeffrey A. Hooke,Craig D. Shriver +7 more
TL;DR: Greater genomic instability in outer quadrants can partially explain the propensity for breast cancers to develop there, rather than simple volume-related concepts.
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Functional identity of genes detectable in expression profiling assays following globin mRNA reduction of peripheral blood samples.
Lori A. Field,Rick Jordan,Jennifer A. Hadix,Michael A. Dunn,Craig D. Shriver,Rachel E. Ellsworth,Darrell L. Ellsworth +6 more
TL;DR: Additional genes detectable only after globin reduction in whole-blood RNA function in a variety of biological processes that may be important to diverse fields of study.
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•Journal Article
High-Throughput Loss of Heterozygosity Mapping in 26 Commonly Deleted Regions in Breast Cancer
Rachel E. Ellsworth,Darrell L. Ellsworth,Susan M. Lubert,Jeff Hooke,Richard I. Somiari,Craig D. Shriver +5 more
TL;DR: This panel of 52 microsatellite markers from 26 of the most commonly deleted regions in breast cancer can be used to quickly detect genomic patterns of loss in large numbers of breast tumor samples and may provide both clinical information and molecular information regarding the underlying tumor suppressor genes.
FH535 inhibited migration and growth of breast cancer cells.
Joji Iida,Jesse Dorchak,John R. Lehman,Rebecca Clancy,Chunqing Luo,Yaqin Chen,Stella Somiari,Rachel E. Ellsworth,Hai Hu,Richard J. Mural,Craig D. Shriver +10 more
TL;DR: Tests of FH535 as a potential inhibitor for malignant phenotypes of breast cancer cells including migration, invasion, and growth suggest not only a mechanism for migration and invasion involving the canonical WNT-signaling pathways but also novel strategies for treating patients who develop TN breast cancer.
Chromosomal alterations associated with the transition from in situ to invasive breast cancer.
Rachel E. Ellsworth,Amy Vertrees,Brad Love,Jeffrey A. Hooke,Darrell L. Ellsworth,Craig D. Shriver +5 more
TL;DR: Lower levels of AI in low-grade in situ compared with invasive disease may reflect the protracted time to progression associated with low- grade DCIS, while increased levels ofAI at chromosomes 1p36 and 11q23 in poorly differentiated carcinomas may harbor genes associated with invasiveness, while loss of chromosome 16q11–q22 may prevent the transition from in situ to invasive disease.
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