R. Scott Thies
Geron Corporation
31 Papers
380 Citations
R. Scott Thies is an academic researcher from Geron Corporation. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 17, co-authored 28 publications. Previous affiliations of R. Scott Thies include Genetics Institute, Inc..
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Papers
Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9.
TL;DR: In cultured neurons, BMP-9 directly induced the expression of the cholinergic gene locus encoding choline acetyltransferase and the vesicular acetylCholine transporter and up-regulated acetylcholine synthesis and these data indicate that B MP-9 is a differentiating factor for cholinerential central nervous system neurons.
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Oligodendrocyte progenitor cells derived from human embryonic stem cells express neurotrophic factors.
TL;DR: It is demonstrated that hES cell-derived OPCs express functional levels of midkine, hepatocyte growth factor (HGF), activin A, transforming growth factor-beta2 (TGF- beta2), and brain-derived neurotrophic factor (BDNF), proteins with reported trophic effects on neurons.
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Heart specific expression of mouse BMP-10 a novel member of the TGF-β superfamily
TL;DR: The data presented here suggest that BMP-10 plays an important role in trabeculation of the embryonic heart.
164
Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes.
TL;DR: Data suggest that BMP‐2 initiates the differentiation of limb bud cells into cells of both the cartilage and bone lineages in a sequential manner, making B MP‐2 a potent regulator of skeletal cell differentiation.
162
MPSS profiling of human embryonic stem cells.
Ralph Brandenberger,Irina Khrebtukova,R. Scott Thies,Takumi Miura,Cai Jingli,Raj K. Puri,Thomas J. Vasicek,Jane S. Lebkowski,Mahendra S. Rao,Mahendra S. Rao +9 more
TL;DR: This analysis provides a molecular signature of genes expressed by undifferentiated ES cells that can be used to monitor the state of ES cells isolated by different laboratories using independent methods and maintained under differing culture conditions.