R. S. K. Chaganti
Memorial Sloan Kettering Cancer Center
202 Papers
4.5K Citations
R. S. K. Chaganti is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Gene & Germ cell tumors. The author has an hindex of 66, co-authored 202 publications. Previous affiliations of R. S. K. Chaganti include Memorial Hospital of South Bend.
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Papers
Abnormalities of 2q: A common genetic link between rhabdomyosarcoma and hepatoblastoma?
TL;DR: The data suggest that malignant differentiation of a teratoma is accompanied by the development of chromosome abnormalities specific for the transformed histology and further suggest that 2q abnormalities may be the common genetic link in theDevelopment of the two histologically unrelated tumor types, embryonal rhabdomyosarcoma and hepatoblastoma.
67
•Journal Article
Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
TL;DR: FISH has used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50,NF-k Kappa Bp65, and lyt-10, and the map position of lyt,10, inferred from its isolation from a t(10;14)(q24;q32) translocation is confirmed.
67
Chromosome abnormalities of leukaemic B lymphocytes in chronic lymphocytic leukaemia
TL;DR: Conventional G- and Q-banding techniques for karyotypic analysis were carried out on the leukaemic lymphocytes induced to divide in vitro and on the cells of the leukemic lymphoblastoid lines.
65
•Journal Article
Expression profiling of lineage differentiation in pluripotential human embryonal carcinoma cells
TL;DR: Time-response analysis via clustering of >12,000 human transcripts revealed distinct stages in the transition from an EC cell to neuronal progenitor cells expressing patterning markers compatible with posterior hindbrain fates followed by the appearance of immature postmitotic neurons with an evolving synaptic apparatus.
61
The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts the V kappa locus
Beverly S. Emanuel,Jules R. Selden,R. S. K. Chaganti,Suresh C. Jhanwar,Peter C. Nowell,Carlo M. Croce +5 more
TL;DR: Results provide direct evidence for translocation-related rearrangement of the kappa immunoglobulin gene cluster in this Burkitt lymphoma and for the assignment of the V kappa locus to 2p11.2.2, the chromosome 2 breakpoint of the 2;8 translocation.
59