R. S. K. Chaganti
Memorial Sloan Kettering Cancer Center
202 Papers
4.5K Citations
R. S. K. Chaganti is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Gene & Germ cell tumors. The author has an hindex of 66, co-authored 202 publications. Previous affiliations of R. S. K. Chaganti include Memorial Hospital of South Bend.
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Papers
•Journal Article
Genetic changes in epithelial solid neoplasia.
TL;DR: Comparison of the patterns of chromosomal (and the underlying molecular) changes in tumors between major embryological cell types demonstrates fundamental differences in genetic mechanisms which lead to tumorigenesis.
Cell of origin, germinal center versus nongerminal center, determined by immunohistochemistry on tissue microarray, does not correlate with outcome in patients with relapsed and refractory DLBCL
Craig H. Moskowitz,Andrew D. Zelenetz,Tarun Kewalramani,Paul A. Hamlin,Simone Lessac-Chenen,Jane Houldsworth,Adam B. Olshen,R. S. K. Chaganti,Stephen D. Nimer,Julie Teruya-Feldstein +9 more
TL;DR: The cell of origin as determined by IHC does not predict outcome in transplantation-eligible patients with relapsed or primary refractory DLBCL, and clinical factors were well balanced between the cohorts.
91
Reconstitution of normal megakaryocytopoiesis and immunologic functions in Wiskott-Aldrich syndrome by marrow transplantation following myeloablation and immunosuppression with busulfan and cyclophosphamide
Kapoor N,D Kirkpatrick,Blaese Rm,J Oleske,MH Hilgartner,R. S. K. Chaganti,Robert A. Good,R.J. O'Reilly +7 more
TL;DR: The use of busulfan in moderate dosages as a myeloablative agent, coupled with cyclophosphamide, may offer an improved alternative to the use of lethal total body irradiation as a preparative regimen for complete correction of Wiskott- Aldrich syndrome by marrow transplantation.
82
Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and diffuse large-B-cell lymphoma
Nallasivam Palanisamy,Ashraf A. Abou-Elella,Seeta R. Chaganti,Jane Houldsworth,Kenneth Offit,Diane C. Louie,Julie Terayu-Feldstein,Juan C. Cigudosa,Pulivarthi H. Rao,Warren G. Sanger,Dennis D. Weisenburger,R. S. K. Chaganti +11 more
TL;DR: It is concluded that PMLBCL is a distinct entity among GC‐derived high‐grade DLBCLs, indicating an origin from a germinal center (GC)–derived B cell.
76
Leukemia Relapse in Donor Cells after Allogeneic Bone-Marrow Transplantation
Peter E. Newburger,Samuel A. Latt,John M. Pesando,Karen M. Gustashaw,Margaret Powers,R. S. K. Chaganti,Richard J. O'Reilly +6 more
TL;DR: It is shown that conventional chemotherapy with allogeneic bone-marrow transplantation is the only treatment capable of producing long-term unmaintained remission in patients with acute leukemia.
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