R Ragheb
University of Cambridge
5 Papers
3 Citations
R Ragheb is an academic researcher from University of Cambridge. The author has contributed to research in topics: Chromatin & Induced pluripotent stem cell. The author has an hindex of 2, co-authored 2 publications.
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Papers
Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics
Srinjan Basu,Ofir Shukron,Aleks Ponjavic,P Parruto,Wayne Boucher,Wei Zhang,Nicola Reynolds,David Lando,D Shah,LH Sober,A Jartseva,R Ragheb,Julie Cramard,Robin Floyd,Guy C. Brown,K Gor,J Balmer,TA Drury,Alexander R. Carr,L-M Needham,Alice Aubert,G Communie,Lluis Morey,Enrique J. Blanco,Michael Barber,Irina Mohorianu,Till Bartke,L Di Croce,Imre Berger,Christiane Schaffitzel,Steven F. Lee,Tim J. Stevens,David Klenerman,Brian Hendrich,David Holcman,Ernest D. Laue +35 more
TL;DR: An intimate connection between a chromatin remodeller and the spatial dynamics of the local regions of the genome to which it binds is uncovered, uncovering a rare fast-diffusing state of NuRD bound enhancers that exhibits directed motion.
Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by NuRD
R Ragheb,Sarah Gharbi,Julie Cramard,Ogundele O,Susan L. Kloet,Thomas Burgold,Michiel Vermeulen,Nicola Reynolds,Brian Hendrich +8 more
TL;DR: It is found that, whereas in mouse primed stem cells and in mouse naïve ES cells, NuRD is required for an appropriate level of transcriptional response to differentiation signals, hiPSCs require NuRD to initiate these responses, which indicates that mouse and human cells interpret and respond to induction of differentiation differently.
Enhancer-promoter interactions are reconfigured through the formation of long-range multiway chromatin hubs as mouse ES cells exit pluripotency
David Lando,X. Ma,A Jartseva,Tim J. Stevens,Wayne Boucher,Nicola Reynolds,Bertille Montibus,D. Hall,Andreas Lackner,R Ragheb,Martin Leeb,B. Hendrich,E. Laue +12 more
TL;DR: The first 3D genome structures of single mouse ES cells as they are induced to exit pluripotency, transition through a formative stage and undergo neuroectodermal differentiation are reported in this article .
The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells
TL;DR: In this article , the nucleosome remodeling and deacetylation (NuRD) complex is used to restrict expression of genes primed for activation upon exit from the pluripotent state.
Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.
David Lando,Yang Cao,A Jartseva,T. J. Stevens,W. Boucher,Nicola Reynolds,Bertille Montibus,D. Hall,Andreas Lackner,R Ragheb,Martin Leeb,B. Hendrich,Ernest D. Laue +12 more
TL;DR: Mouse ES cells exiting pluripotency undergo significant 3D genome reorganization, forming long-range multiway hubs that bring together enhancers and promoters from distant chromosomal sites, facilitating gene expression changes and cell identity establishment.