R. P. Moseley
Frenchay Hospital
7 Papers
75 Citations
R. P. Moseley is an academic researcher from Frenchay Hospital. The author has contributed to research in topics: Neoplastic meningitis & Meningitis. The author has an hindex of 6, co-authored 7 publications.
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Papers
•Journal Article
Pharmacokinetics and Tumor Localization of 131I-Labeled Anti-Tenascin Monoclonal Antibody 81C6 in Patients with Gliomas and Other Intracranial Malignancies
TL;DR: These studies demonstrate that the tumor uptake of 131I-labeled 81C6 in patients with gliomas and other intracranial malignancies is due to specific processes.
164
Carcinomatous meningitis: antibody-guided therapy with I-131 HMFG1.
R. P. Moseley,J C Benjamin,R D Ashpole,N. M. Sullivan,J A Bullimore,H.B. Coakham,John T. Kemshead +6 more
TL;DR: Seven patients with carcinomatous meningitis were administered intrathecal I-131 labelled monoclonal antibody HMFG1 and partial obliteration of the subarachnoid space was identified as a potential problem in patients with advanced disease.
28
Immunoreactivity, pharmacokinetics and bone marrow dosimetry of intrathecal radioimmunoconjugates.
R. P. Moseley,V. Papanastassiou,Michael R. Zalutsky,R. D. Ashpole,S. Evans,Darell D. Bigner,John T. Kemshead +6 more
TL;DR: Ten patients with neoplastic meningitis were treated with a variety of 1311‐monoclonal antibody (MAb) conjugates, chosen to bind to their particular malignancy, and Pharmacokinetic studies revealed that MAbs leave the ventricular compartment, enter the sub‐arachnoid space and then pass into the blood.
23
HMFG1 antigen: a new marker for carcinomatous meningitis.
R. P. Moseley,K. Oge,Saad Shafqat,C. M. Moseley,N. M. Sullivan,R. A. Badley,Joy Burchell,Joyce Taylor-Papadimitriou,Hugh B. Coakham +8 more
TL;DR: In a series of 100 patients, an epithelial associated glycoprotein (HMFGI antigen) in CSF obtained at lumbar puncture was assayed for, and in 18 of 20 patients with carcinomatous meningitis, this high‐molecular‐weight glycop protein was detectable in the CSF.
16
Neoplastic meningitis in malignant melanoma: diagnosis with monoclonal antibodies.
TL;DR: The addition of monoclonal antibody immunocytology to conventional techniques significantly improved the diagnostic sensitivity of CSF cytology, allowing for earlier and therefore more effective palliative treatment of neoplastic melanomatous meningitis.
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