R Mueller
7 Papers
75 Citations
R Mueller is an academic researcher. The author has contributed to research in topics: Breast cancer & Downregulation and upregulation. The author has an hindex of 6, co-authored 7 publications.
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Papers
Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations.
Gernot Hudelist,T Wagner,Marsha Rich Rosner,Anneliese Fink-Retter,Daphne Gschwantler-Kaulich,Klaus Czerwenka,Regina Kroiss,Muy-Kheng Tea,K. Pischinger,Wolfgang J. Köstler,Johannes Attems,R Mueller,C Blaukopf,Ernst Kubista,Markus Hengstschläger,Christian F. Singer +15 more
TL;DR: In this article, the effect of BRCA mutations on intracellular IGF-I protein expression was detected in tumoral epithelium and surrounding stroma, and was significantly upregulated in tumors of mutation carriers when compared with matched sporadic tumors.
Active (p)CrkL is overexpressed in human malignancies: Potential role as a surrogate parameter for therapeutic tyrosine kinase inhibition
Christian F. Singer,Gernot Hudelist,Wolfgang Lamm,R Mueller,Claudia Handl,Ernst Kubista,Klaus Czerwenka +6 more
TL;DR: In this article, protein expression of activated (p)CrkL in normal and malignant tissues was analyzed using immunohistochemistry, and the effect of tyrosine kinase inhibition on CrkL activation was analyzed.
Differential spatial expression and activation pattern of EGFR and HER2 in human breast cancer.
Anneliese Fink-Retter,Daphne Gschwantler-Kaulich,Gernot Hudelist,R Mueller,Ernst Kubista,Klaus Czerwenka,Christian F. Singer +6 more
TL;DR: The findings of decreased intratumoral EGFR expression and the absence of activated EGFR suggests that, in contrast to HER2, EGFR inhibition might not be an ideal target for antibody therapy.
EGFR activity in HER-2 over-expressing metastatic breast cancer: evidence for simultaneous phosphorylation of Her-2/neu and EGFR.
Daphne Gschwantler-Kaulich,Gernot Hudelist,Wolfgang J. Koestler,Klaus Czerwenka,R Mueller,Samir Helmy,Ernst Ruecklinger,Ernst Kubista,Christian F. Singer +8 more
TL;DR: It is suggested that EGFR inhibition might enhance the efficacy of trastuzumab by preventing cross-phosphorylation and demonstrated the activation pattern of EGFR and Her-2/ neu in Her- 2/neu overexpressing breast cancer.
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Selective spatial upregulation of intratumoral stromal aromatase in breast cancer patients: evidence for imbalance of local estrogen metabolism.
Christian F. Singer,Anneliese Fink-Retter,Daphne Gschwantler-Kaulich,Theresia Thalhammer,Gernot Hudelist,R Mueller,Klaus Czerwenka,Ernst Kubista +7 more
TL;DR: A net increase in intratumoral active estrogen levels through increased stromal aromatization, while physiological local inactivation by sulfotransferase activity remains essentially unchanged is indicated.