Melanomzellen konnen durch zytotoxische T-Lymphozyten (CTL) erkannt und hochspezifisch lysiert werden (siehe auch Vakzinationstherapie beim Melanom). Die Erkennung erfolgt HLA-Klasse I-abhangig in Verbindung mit definierten Peptiden von 8–10 Aminosauren Lange, die sich von den Melanom-assozierten Antigenen herleiten. Eine Aufstellung, der z. Z. bereits identifizierten Melanom-assozierten Antigene und der bekannten Peptide ist in Tabelle 1 zu finden.

Phase II-Studie zur Vakzinierung von Melanompatienten mit Tyrosinase-Peptiden und GM-CSF

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Phase II-Studie zur Vakzinierung von Melanompatienten mit Tyrosinase-Peptiden und GM-CSF