R. L. Sutherland
Garvan Institute of Medical Research
22 Papers
404 Citations
R. L. Sutherland is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Prostate cancer & Pancreatic cancer. The author has an hindex of 11, co-authored 22 publications.
Chat about Author
Papers
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey,David K. Chang,Katia Nones,Katia Nones,Amber L. Johns,Ann-Marie Patch,Ann-Marie Patch,Marie-Claude Gingras,David Miller,David Miller,Angelika N. Christ,Timothy J. C. Bruxner,Michael C.J. Quinn,Michael C.J. Quinn,Craig Nourse,Craig Nourse,Murtaugh Lc,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Ehsan Nourbakhsh,Shivangi Wani,Shivangi Wani,J. Lynn Fink,Oliver Holmes,Oliver Holmes,Chin,Matthew J. Anderson,Stephen H. Kazakoff,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Felicity Newell,Nicola Waddell,Scott Wood,Scott Wood,Qinying Xu,Qinying Xu,Peter J. Wilson,Nicole Cloonan,Nicole Cloonan,Karin S. Kassahn,Karin S. Kassahn,Karin S. Kassahn,Darrin Taylor,Kelly Quek,Alan J. Robertson,Lorena Pantano,Laura Mincarelli,Luis Navarro Sanchez,Lisa Evers,Jianmin Wu,Mark Pinese,Mark J. Cowley,Jones,Jones,Emily K. Colvin,Adnan Nagrial,Emily S. Humphrey,Lorraine A. Chantrill,Lorraine A. Chantrill,Amanda Mawson,Jeremy L. Humphris,Angela Chou,Angela Chou,Marina Pajic,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Jessica A. Lovell,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Kim Moran-Jones,Nigel B. Jamieson,Janet Graham,Janet Graham,Fraser Duthie,Karin A. Oien,Karin A. Oien,Hair J,Robert Grützmann,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Corbo,Claudio Bassi,Borislav Rusev,Paola Capelli,Roberto Salvia,Giampaolo Tortora,Debabrata Mukhopadhyay,Gloria M. Petersen,Munzy Dm,William E. Fisher,Saadia A. Karim,Eshleman,Ralph H. Hruban,Christian Pilarsky,Jennifer P. Morton,Owen J. Sansom,Aldo Scarpa,Elizabeth A. Musgrove,Ulla-Maja Bailey,Oliver Hofmann,Oliver Hofmann,R. L. Sutherland,David A. Wheeler,Anthony J. Gill,Anthony J. Gill,Richard A. Gibbs,John V. Pearson,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond,Sean M. Grimmond,Sean M. Grimmond +128 more
TL;DR: Detailed genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT signalling, G1/S transition, SWI-SNF, chromatin modification, DNA repair and RNA processing.
3.2K
Androgen receptor inhibits estrogen receptor-A activity and is prognostic in breast cancer
Amelia A. Peters,Grant Buchanan,Carmela Ricciardelli,Tina Bianco-Miotto,Margaret M. Centenera,Jonathan M. Harris,Shalini Jindal,Davendra Segara,Li Jia,Nicole L. Moore,Susan M. Henshall,Stephen N. Birrell,Gerhard A. Coetzee,R. L. Sutherland,Lisa M. Butler,Wayne D. Tilley +15 more
- 01 Jan 2009
TL;DR: In this paper, the balance between estrogen receptor-α (ERα) and androgen receptor (AR) signaling is a critical determinant of growth in the normal and malignant breast.
279
A role for GATA-2 in transition to an aggressive phenotype in prostate cancer through modulation of key androgen-regulated genes.
Maret Böhm,Warwick J. Locke,R. L. Sutherland,James G. Kench,James G. Kench,Susan M. Henshall +5 more
TL;DR: The results indicate that upregulation of GATA-2 may contribute to the progression to aggressive prostate cancer through modulation of expression of AR and key androgen-regulated genes, one of which, AZGP1, is associated with the progression with metastatic disease.
94
Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer
Toby Hulf,Tennille Sibbritt,Erik D Wiklund,Erik D Wiklund,Kate I. Patterson,Jenny Z. Song,Clare Stirzaker,Wenjia Qu,Shalima S. Nair,Lisa G. Horvath,Lisa G. Horvath,Nicola J. Armstrong,Nicola J. Armstrong,James G. Kench,James G. Kench,R. L. Sutherland,Susan J. Clark,Susan J. Clark +17 more
TL;DR: It is suggested that miR-205 is an epigenetically regulated tumor suppressor that targets MED1 and may provide a potential biomarker in prostate cancer management.
91
Expression of the androgen receptor and an androgen-responsive protein, apolipoprotein D, in human breast cancer
R. E. Hall,James O. Aspinall,David J. Horsfall,Stephen N. Birrell,Jacqueline M. Bentel,R. L. Sutherland,Wayne D. Tilley +6 more
TL;DR: Although apo-D expression is androgen regulated in human breast cancer cell lines in vitro, its expression in primary breast cancers may be regulated by other factors, which suggests that the receptor may be involved in tumour responsiveness or in abnormal responses to endocrine therapies.
75