Synthesis and characterization of humic acid-like polymers

Depletion of Hepatic Glutathione in The Guinea-Pig after Administration of (±)-Buthionine Sulphoxime C. M. LAZENBY, E. S. HARPUR, A.GESCHER, and S. J. LEE . . . . . . . . . P 3 The Acute Effect of Buthione Sulphoxime on the Glutathione Content of Mouse Liver B. BAL and A. POOLE. . . . . . . . . . . . . . . . . . . . . P 3 How Much Can Arsenate Compete with Phosphate in Living Cells? A. E. PEEL, M. IMBENOTTE, G. VERMEERSCH, and F. ERB . . . . . . P4 Effect of Exposure Time on the In Vitro Teratogenicity of Retinoic Acid R. MARLOW, L. REILLY, and C. E. STEELE . . . . . . . . . . . . . . P 4 The Effect of Organic Solvents on Human Erythrocyte Membrane Adenosine Triphosphatase Activities In Vitro H. TAHTI and M. KORPELA . . . . . . . . . . . . . . . . . . . . P4 The Perchlorate Discharge Test for Examining Thyroid Function in Rats C. K. ATTERWILL, P. COLLINS, C. G. BROWN, and R. F. HARLAND. . . . P 5 Pathological Changes in the Liver BALBjc Mice Induced by N-Methylformamide P. G. PEARSON, I. S. PRATT, A. GESCHER, and E. S. HARPUR. . . . . . . . . . . P 5 The Effect of 1,3-Dinitrobenzene and Mono-(2-Ethylhexyl) phthalate on Lactate and Pyruvate Production by Rat Sertoli Cell Cultures J. WILLIAMS and P. M. D. FOSTER. . . . . . . . . . . P 6 Toxicity of the Potential Antineoplastic Agent Ambazone U. HORN, A. HARTL, 1. GUITNER, and H. HOFFMANN P6 Reproduction Study of Rifaximin (Lj105) In Rats G. BORELLI and D. BERTOLI . . . . . . . . . . . P 7 An Aid to the Maintenance of Disease-Free Animals G. CLOUGH and J.R. NEEDHAM P7

Mechanisms and Models in Toxicology

A great number of chemicals and naturally occurring substances cause toxicity in cells in the form of an increase of cell membrane permeability. This kind of pathological cell alteration can be sensitively detected in vitro by measuring the accelerated chromium-51 release of suitable target cells (Zawydiwski and Duncan 1978).

Cell membrane toxicity detected with the chromium-51 release test.

Reduktiver Abbau einer Huminsäure-Modellsubstanz: Nachweis der Abbauprodukte mittels Chromatographie

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Reduktiver Abbau einer Huminsäure-Modellsubstanz: Nachweis der Abbauprodukte mittels Chromatographie