BACKGROUND/AIMS Between June 1992 and July 1995, 29 uveal melanomas were treated radiosurgically with the Leksell gamma unit at the University of Graz. The aim of this retrospective study was to examine the pattern of regression and the extent and time period of the decrease in tumour size. METHODS The Leksell gamma knife, model B, was used. Patients were divided into three groups according to marginal dose: group 1: eight patients with a marginal dose >50 Gy, group 2: 15 patients with a marginal dose = 50 Gy, and group 3: six patients with a marginal dose = 45 Gy. For the retrospective study two groups were examined: group A, tumours RESULTS No significant correlation was found between tumour regression and the marginal dose. Tumour shrinkage depends on the pretreatment height. In the group of eight patients with an initial tumour prominence of less than 5 mm, no prominence was found after therapy. In the group of patients with an original tumour prominence of 5 mm and more, only two tumours formed a flat scar while a residual prominence was found in 18 patients. Increase in reflectivity combined with a decrease in size appears to be a good criterion for the effectiveness of the treatment. In five patients with tumours showing low reflectivity, over a longer period of time metastases were found. An enucleation was performed in two patients because of uncertain tumour regression and in one patient as a result of an increase in tumour size. CONCLUSION The pattern of echographic reflectivity and decrease in size is similar to brachytherapy and is one of the most important diagnostic variables for evaluation of tumour regression. An increase in reflectivity as well as a decrease in tumour size in the first 6-8 months can be considered a therapeutic success.

https://bjo.bmj.com/content/bjophthalmol/82/2/154.full.pdf

Echographic findings in uveal melanomas treated with the Leksell gamma knife

Ultrasound in cryosurgery

http://www.scielo.br/pdf/clin/v61n1/a14v61n1.pdf

Atypical choroidal melanoma: report of 3 cases.

Diagnostic Ophthalmic Ultrasound

Echographic Examinations on 110 Histologically Proven Intraocular Melanomas

The ultrasonographic findings in 39 cases of malignant melanoma of the choroid has been correlated with histopathological results. Tumors with hemorrhages and/or necrosis showed a lower reflectivity than those with a higher amount of connection tissue. B-scan ultrasonography was found to be reliable for the measurement of the extent of the tumor in all three dimensions.

[Some correlations between ultrasonographic and histopathologic findings in malignant melanoma of the choroid (author's transl)].

Report of a 71-year-old woman with acute closed-angle glaucoma. Echography shows an intraocular tumor of the choroid, and the histological diagnosis is necrotic malignant melanoma of the choroid. The clinical, echographical and histological findings are discussed.

Nekrotisches malignes Melanom der Aderhaut mit ungewöhnlichem klinischem Verlauf

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[Some correlations between ultrasonographic and histopathologic findings in malignant melanoma of the choroid (author's transl)].

Nekrotisches malignes Melanom der Aderhaut mit ungewöhnlichem klinischem Verlauf