R. D. Hill
Harvard University
13 Papers
248 Citations
R. D. Hill is an academic researcher from Harvard University. The author has contributed to research in topics: Mammalian diving reflex & Thromboxane. The author has an hindex of 11, co-authored 13 publications.
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Papers
Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction
Fabrizio Michelassi,L Landa,R. D. Hill,Edward Lowenstein,Watkins Wd,A J Petkau,Warren M. Zapol +6 more
TL;DR: Intravenous FPL 55712 completely abolished the coronary vasoconstriction of leukotriene D4, but a significant reduction of regional wall shortening persisted, and this cardiac effect was neither inhibited by prior treatment of the sheep with a cyclooxygenase inhibitor nor associated with thromboxane B2 release into the coronary sinus.
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Heart rate and body temperature during free diving of Weddell seals
R. D. Hill,Robert C. Schneider,Graham C. Liggins,A. H. Schuette,R. L. Elliott,Michael Guppy,Peter W. Hochachka,J. Qvist,K. J. Falke,Warren M. Zapol +9 more
TL;DR: The first microprocessor-controlled monitors for collection of data on depth, heart rate, and body temperature of one fetal and five adult male freely swimming Weddell seals are developed and successfully used.
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Bedside Measurement of Pulmonary Capillary Pressure in Patients with Acute Respiratory Failure
TL;DR: The results indicate that a discrete value for pulmonary capillary pressure can be reproducibly measured in paralyzed ventilated patients and suggest that there is unequal and variable partitioning of the increased PVR during acute respiratory failure.
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Protective metabolic mechanisms during liver ischemia: transferable lessons from long-diving animals.
Peter W. Hochachka,J. M. Castellini,R. D. Hill,Robert C. Schneider,J. L. Bengtson,S. E. Hill,Graham C. Liggins,Warren M. Zapol +7 more
TL;DR: An interesting parallelism (channel arrest coupled with a proportionate metabolic arrest at the level of both glycolysis and the ETS) appears as the dominant Hypoxia defense strategy in a hypoxia-tolerant mammalian organ.
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•Journal Article
Effects of leukotrienes B4 and C4 on coronary circulation and myocardial contractility.
Fabrizio Michelassi,G Castorena,R. D. Hill,Edward Lowenstein,Watkins Wd,A J Petkau,Warren M. Zapol +6 more
TL;DR: Leukotriene B4 and C4 were injected directly into the left circumflex coronary artery of nine anesthetized Suffolk sheep and FPL 55712, a receptor antagonist of leukotrienes C4, D4, and E4, blocked the vasoconstriction induced by L TC4 but only partially blocked the negative inotropic effects of LTC4.
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