R. Connolly
Queen's University Belfast
5 Papers
8 Citations
R. Connolly is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Malignancy & Chromogranin A. The author has an hindex of 2, co-authored 5 publications.
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Papers
Cox-2 promotes chromogranin A expression and bioactivity: evidence for a prostaglandin E2-dependent mechanism and the involvement of a proximal cyclic adenosine 5'-monophosphate-responsive element.
R. Connolly,Damien Gates,Nellie Loh,Dilair Baban,Rajesh Thakker,Brian T. Johnston,David R. McCance,Joy Ardill,Daniel T. O'Connor,Laurent Taupenot,Ann McGinty +10 more
TL;DR: This study is the first to demonstrate that Cox-2 up-regulates both CGA expression and bioactivity in a neuro endocrine cell line and has major implications for the role of this polypeptide in the pathogenesis of neuroendocrine cancers in which Cox- 2 is up-regulated.
6
An investigation into the role of Bcl-2 in neuroendocrine differentiation.
I.S. Cadden,Brian T. Johnston,R. Connolly,Damien Gates,Yoshihide Tsujimoto,Yutaka Eguchi,Ann McGinty +6 more
TL;DR: The hypothesis that Bcl-2 promotes the acquisition of a neuroendocrine phenotype is not supported as the results of this study do not support the hypothesis.
2
Apo J/clusterin expression and secretion: Evidence for 15-deoxy-Δ12,14-PGJ2-dependent mechanism
Damien Gates,Kiera Dollin,R. Connolly,Ian S. Young,Lesley Powell,Jane McEneny,Martin E. Gleave,Ann McGinty +7 more
TL;DR: Results indicate that Cox-2 induces clusterin in a 15d-PGJ(2)-dependent manner, and via activation of HSF-1 and PPARγ, however, the results do not support a model whereby Cox- 2/15d- PGJ( 2)-dependent inhibition of NF-κB signalling involves clusterin.
2
Cyclooxygenase‐2 expression correlates with phaeochromocytoma malignancy: evidence for a Bcl‐2‐dependent mechanism
I.S. Cadden,A.B. Atkinson,Brian T. Johnston,K. Pogue,R. Connolly,D McCance,Joy Ardill,C.F. Russell,Ann McGinty +8 more
TL;DR: Cyclooxygenase (COX)‐2 and Bcl‐2 are evaluated as tissue‐based biomarkers of phaeochromocytoma prognosis and are found to be reliable markers for benign and malignant tumours respectively.