R. Brink
5 Papers
R. Brink is an academic researcher. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 2, co-authored 5 publications.
Chat about Author
Papers
Epithelial-derived oxysterol production tunes intestinal IgA secretion against commensals and enteric pathogen in tissue
Simona Ceglia,Alyssa Berthelette,Kelsey Howley,Yun Li,Nicole K.H. Yiew,Ying Xu,R. Brink,Jason G. Cyster,Lora V. Hooper,Gwendalyn J. Randolph,Andrea Reboldi +10 more
TL;DR: In this article , the authors demonstrated that intestinal epithelial cells (IECs) integrate luminal input to produce 7α,25-dihydroxycholesterol (7α, 25-HC), a cholesterol metabolite with immunomodulatory functions.
Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice
TL;DR: In this article , the DNA-binding exons 5-8 of Trp53, the mouse ortholog of human TP53, with variant-CpG (either CpG-depleted or -enriched) sequences predicted to encode the normal p53 amino acid sequence were synonymously substituted.
An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells
Simona Ceglia,Alyssa Berthelette,Kelsey Howley,Yun Li,Benedikt M Mortzfeld,Shakti K. Bhattarai,Nicole K.H. Yiew,Ying Xu,R. Brink,Jason G. Cyster,Lora V. Hooper,Gwendalyn J. Randolph,Vanni Bucci,Andrea Reboldi +13 more
TL;DR: It is shown that dietary cholesterol absorption and commensal recognition by duodenal intestinal epithelial cells lead to the production of oxysterols, evolutionarily conserved lipids with immunomodulatory functions and revealed a new mechanism linking dietary cholesterol and humoral immune responses centered around plasma cell localization for efficient mucosal protection.
CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1+ ICOShigh activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells
Etienne Masle-Farquhar,Yogesh Jeelall,Jacqueline White,Julia Bier,Elissa K. Deenick,R. Brink,Keisuke Horikawa,Christopher C. Goodnow +7 more
TL;DR: In this article , a Germline Card11 gain-of-function (GOF) mutation was found to cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell lymphomas (PTCL) adult T cell leukemia/lymphoma (ATL), cutaneous T cell cancer (CTCL) and Sezary Syndrome.
Skin γδ T cell inflammatory responses are hardwired in the thymus by oxysterol sensing via GPR183 and calibrated by dietary cholesterol.
Michela Frascoli,Enxhi Ferraj,Bing Miu,Justin Lewis Malin,Nicholas A. Spidale,Jennifer E. Cowan,Susannah C. Shissler,R. Brink,Ying Xu,Jason G. Cyster,Avinash Bhandoola,Joonsoo Kang,Andrea Reboldi +12 more
TL;DR: In this article , the authors investigated how sensing of cholesterol metabolite oxysterols by γδ T cells impacts their tissue residency and function, implicating diet as a focal parameter of dermal Tγδ17 cells.