R. A. Tasker
University of Prince Edward Island
15 Papers
216 Citations
R. A. Tasker is an academic researcher from University of Prince Edward Island. The author has contributed to research in topics: Kainic acid & Hippocampal formation. The author has an hindex of 10, co-authored 15 publications.
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Papers
Comparative behavioural toxicity of domoic acid and kainic acid in neonatal rats
TL;DR: Comparisons between DOM and kainic acid revealed that DOM was approximately six-fold more potent than kainate at both PND 8 and PND 14 and that both toxins were approximately two-fold less potent in P ND 14 rats, compared to PND8, which implies that the mechanism(s) responsible for reduced potency is/are similar between the two compounds.
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Gender-based changes in cognition and emotionality in a new rat model of epilepsy
TL;DR: It is concluded that perinatal treatment with low doses of domoic acid results in significant gender-based changes in cognition and emotionality in adult rats.
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NMDA receptor involvement in the effects of low dose domoic acid in neonatal rats.
TL;DR: The results indicate that a very low dose of DOM produces a conditioned odour preference in neonatal rats and that this effect is due in part to NMDA receptor involvement, thereby emphasizing a role for both kainate and NMDA glutamate receptors in implicit memory.
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Enhanced neurogenesis in organotypic cultures of rat hippocampus after transient subfield-selective excitotoxic insult induced by domoic acid
Anabel Pérez-Gómez,R. A. Tasker +1 more
TL;DR: It is shown that exposure of OHSC to concentrations of DOM below those required to induce permanent neurotoxicity can induce proliferation and differentiation of neural progenitor cells that may contribute to recovery from mild injury and to develop abnormal circuits relevant to disease.
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Neonatal exposure to low-dose domoic acid lowers seizure threshold in adult rats
TL;DR: It is concluded that perinatal exposure to subconvulsive doses of DOM results in permanent changes in neuronal excitability in the adult rat, as demonstrated by a lowering of both generalized seizure and focal afterdischarge threshold, and produces increased MFS following kindling.
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