Quinte Braster
Ludwig Maximilian University of Munich
10 Papers
34 Citations
Quinte Braster is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Medicine & Inflammation. The author has an hindex of 7, co-authored 10 publications.
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Papers
Neutrophils as regulators of cardiovascular inflammation.
Carlos Silvestre-Roig,Quinte Braster,Almudena Ortega-Gomez,Oliver Soehnlein,Oliver Soehnlein +4 more
TL;DR: The influence of traditional and novel cardiovascular risk factors on neutrophil production and function is discussed and the current knowledge of the contribution of neutrophils to the different stages of atherosclerosis, including atherogenesis, plaque destabilization and plaque erosion is appraised.
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Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.
Carlos Silvestre-Roig,Quinte Braster,Kanin Wichapong,Ernest Y. Lee,Jean Marie Teulon,Nihel Berrebeh,Janine Winter,José M. Adrover,Giancarlo Santiago Santos,Alexander Froese,Patricia Lemnitzer,Almudena Ortega-Gomez,Raphael Chevre,Julian A. Marschner,Ariane Schumski,Carla Winter,Laura Perez-Olivares,Chang Pan,Nicole Paulin,Tom Schoufour,Helene Hartwig,Silvia González-Ramos,Frits Kamp,Remco T. A. Megens,Kerri A. Mowen,Matthias Gunzer,Lars Maegdefessel,Lars Maegdefessel,Tilman M. Hackeng,Esther Lutgens,Mat J.A.P. Daemen,Julia von Blume,Hans-Joachim Anders,Viacheslav O. Nikolaev,Jean-Luc Pellequer,Christian Weber,Christian Weber,Andrés Hidalgo,Andrés Hidalgo,Gerry A. F. Nicolaes,Gerard C. L. Wong,Oliver Soehnlein +41 more
TL;DR: This work demonstrates that extracellular histone H4-mediated membrane lysis of smooth muscle cells (SMCs) triggers arterial tissue damage and inflammation, and identifies a form of cell death found at the core of chronic vascular disease that is instigated by leukocytes and can be targeted therapeutically.
Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases
Renato G.S. Chirivi,Jos W. G. van Rosmalen,Maarten van der Linden,Maximilien Euler,Gonny Schmets,Galina S. Bogatkevich,Konstantinos Kambas,Jonas Hahn,Quinte Braster,Oliver Soehnlein,Oliver Soehnlein,Markus H. Hoffmann,Helmuth H. G. van Es,Jos M.H. Raats +13 more
TL;DR: This work is the first to describe an antibody with NET-inhibiting properties and proposes tACPA as a drug candidate for NET-mediated inflammatory diseases, as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner.
Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.
Yaw Asare,Thomas A. Campbell-James,Yury Bokov,Lydia Luya Yu,Matthias Prestel,Omar El Bounkari,Stefan Roth,Remco T. A. Megens,Remco T. A. Megens,Tobias Straub,Kyra Thomas,Guangyao Yan,Melanie Schneider,Natalie Ziesch,Steffen Tiedt,Carlos Silvestre-Roig,Quinte Braster,Yishu Huang,Manuela Schneider,Rainer Malik,Christof Haffner,Arthur Liesz,Oliver Soehnlein,Oliver Soehnlein,Juergen Bernhagen,Martin Dichgans +25 more
TL;DR: Hdac9 is identified as a regulator of atherosclerotic plaque stability and IKK activation thus providing a mechanistic explanation for the prominence of HDAC9 as a vascular risk locus in genome-wide association studies.
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Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis
Julia Hinterdobler,Simin Schott,Hong Jin,Almut Meesmann,Anna-Lena Steinsiek,Anna-Sophia Zimmermann,Jana Wobst,Philipp Müller,Carina Mauersberger,Baiba Vilne,Alexandra Baecklund,Chien-Sin Chen,Aldo Moggio,Quinte Braster,Michael Molitor,Markus Krane,W.E. Kempf,Karl-Heinz Ladwig,Michael Hristov,Maarten Hulsmans,Ingo Hilgendorf,Christian Weber,Philip Wenzel,Christoph Scheiermann,Christoph Scheiermann,Lars Maegdefessel,Lars Maegdefessel,Oliver Soehnlein,Peter Libby,Matthias Nahrendorf,Heribert Schunkert,Thorsten Kessler,Hendrik B. Sager +32 more
TL;DR: This paper showed that acute mental stress significantly contributes to the initiation and progression of human disease, including cardiovascular conditions, including heart, lung, skin, and, if present, atherosclerotic plaques.